Degree of desmoplasia in metastatic lymph node lesions is associated with lesion size and poor prognosis in pancreatic cancer patients

Hiromichi Nakayama, Kenoki Ohuchida, Masaki Yoshida, Tetsuyuki Miyazaki, Shin Takesue, Toshiya Abe, Sho Endo, Kazuhiro Koikawa, Takashi Okumura, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Kengo Shirahane, Tatsuya Manabe, Takao Ohtsuka, Hiroki Toma, Yohei Tominaga, Eishi Nagai, Kazuhiro Mizumoto, Yoshinao OdaMasafumi Nakamura

Research output: Contribution to journalArticle

Abstract

Pancreatic cancer is characterized by increased hyperplasia of fibrotic tissue, termed desmoplasia, and lymph node metastasis is an independent prognostic factor in this disease. However, there are no reports focused on desmoplasia in pancreatic cancer lymph node metastases. The present study evaluated a range of factors and investigated their association with poor prognosis in pancreatic cancer cases with lymph node metastasis, including the degree of desmoplasia in lesions. To identify the poor prognostic factors associated with lymph node metastasis, the present study retrospectively reviewed the clinical data of 65 patients with lymph node metastases that underwent surgical pancreatic cancer resection between 2007 and 2012 at a single institution. The investigation focused on the degree of fibrosis in metastatic lesions in 216 lymph nodes, and investigated associations with prognosis or clinicopathological findings. The ratios of the fibrotic area in metastatic lymph node lesions were evaluated and classified into three categories, high (≥70%), moderate (10-70%) and low (<10%). Desmoplasia was not observed in cancer-free lymph nodes. The size of metastatic lymph node lesions was additionally measured, and a significant association between metastatic lesion size and the degree of desmoplasia was observed (P<0.001). The degree of desmoplasia was additionally associated with local extranodal invasion. In the analysis of 65 pancreatic cancer patients with metastatic lymph nodes, the presence of multiple metastatic lymph nodes with moderate or high desmoplasia was significantly associated with poor survival (high, P=0.0048; moderate/high, P=0.0075). Of several clinicopathological factors, the presence of multiple metastatic lymph nodes with high or moderate desmoplasia was associated with overall survival in univariate (P=0.0098) and multivariate (P=0.0466) analyses. The degree of desmoplasia in metastatic lymph nodes is associated with lesion size, and the presence of multiple metastatic lymph nodes with desmoplasia is an independent poor prognostic factor, suggesting that the desmoplasia may have an important role in the malignant progression of lymph node metastases.

Original languageEnglish
Pages (from-to)3141-3147
Number of pages7
JournalOncology Letters
Volume14
Issue number3
DOIs
Publication statusPublished - Jan 1 2017

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Pancreatic Neoplasms
Lymph Nodes
Neoplasm Metastasis
Survival
Hyperplasia
Fibrosis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Degree of desmoplasia in metastatic lymph node lesions is associated with lesion size and poor prognosis in pancreatic cancer patients. / Nakayama, Hiromichi; Ohuchida, Kenoki; Yoshida, Masaki; Miyazaki, Tetsuyuki; Takesue, Shin; Abe, Toshiya; Endo, Sho; Koikawa, Kazuhiro; Okumura, Takashi; Moriyama, Taiki; Nakata, Kohei; Miyasaka, Yoshihiro; Shirahane, Kengo; Manabe, Tatsuya; Ohtsuka, Takao; Toma, Hiroki; Tominaga, Yohei; Nagai, Eishi; Mizumoto, Kazuhiro; Oda, Yoshinao; Nakamura, Masafumi.

In: Oncology Letters, Vol. 14, No. 3, 01.01.2017, p. 3141-3147.

Research output: Contribution to journalArticle

Nakayama, H, Ohuchida, K, Yoshida, M, Miyazaki, T, Takesue, S, Abe, T, Endo, S, Koikawa, K, Okumura, T, Moriyama, T, Nakata, K, Miyasaka, Y, Shirahane, K, Manabe, T, Ohtsuka, T, Toma, H, Tominaga, Y, Nagai, E, Mizumoto, K, Oda, Y & Nakamura, M 2017, 'Degree of desmoplasia in metastatic lymph node lesions is associated with lesion size and poor prognosis in pancreatic cancer patients', Oncology Letters, vol. 14, no. 3, pp. 3141-3147. https://doi.org/10.3892/ol.2017.6549
Nakayama, Hiromichi ; Ohuchida, Kenoki ; Yoshida, Masaki ; Miyazaki, Tetsuyuki ; Takesue, Shin ; Abe, Toshiya ; Endo, Sho ; Koikawa, Kazuhiro ; Okumura, Takashi ; Moriyama, Taiki ; Nakata, Kohei ; Miyasaka, Yoshihiro ; Shirahane, Kengo ; Manabe, Tatsuya ; Ohtsuka, Takao ; Toma, Hiroki ; Tominaga, Yohei ; Nagai, Eishi ; Mizumoto, Kazuhiro ; Oda, Yoshinao ; Nakamura, Masafumi. / Degree of desmoplasia in metastatic lymph node lesions is associated with lesion size and poor prognosis in pancreatic cancer patients. In: Oncology Letters. 2017 ; Vol. 14, No. 3. pp. 3141-3147.
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abstract = "Pancreatic cancer is characterized by increased hyperplasia of fibrotic tissue, termed desmoplasia, and lymph node metastasis is an independent prognostic factor in this disease. However, there are no reports focused on desmoplasia in pancreatic cancer lymph node metastases. The present study evaluated a range of factors and investigated their association with poor prognosis in pancreatic cancer cases with lymph node metastasis, including the degree of desmoplasia in lesions. To identify the poor prognostic factors associated with lymph node metastasis, the present study retrospectively reviewed the clinical data of 65 patients with lymph node metastases that underwent surgical pancreatic cancer resection between 2007 and 2012 at a single institution. The investigation focused on the degree of fibrosis in metastatic lesions in 216 lymph nodes, and investigated associations with prognosis or clinicopathological findings. The ratios of the fibrotic area in metastatic lymph node lesions were evaluated and classified into three categories, high (≥70{\%}), moderate (10-70{\%}) and low (<10{\%}). Desmoplasia was not observed in cancer-free lymph nodes. The size of metastatic lymph node lesions was additionally measured, and a significant association between metastatic lesion size and the degree of desmoplasia was observed (P<0.001). The degree of desmoplasia was additionally associated with local extranodal invasion. In the analysis of 65 pancreatic cancer patients with metastatic lymph nodes, the presence of multiple metastatic lymph nodes with moderate or high desmoplasia was significantly associated with poor survival (high, P=0.0048; moderate/high, P=0.0075). Of several clinicopathological factors, the presence of multiple metastatic lymph nodes with high or moderate desmoplasia was associated with overall survival in univariate (P=0.0098) and multivariate (P=0.0466) analyses. The degree of desmoplasia in metastatic lymph nodes is associated with lesion size, and the presence of multiple metastatic lymph nodes with desmoplasia is an independent poor prognostic factor, suggesting that the desmoplasia may have an important role in the malignant progression of lymph node metastases.",
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T1 - Degree of desmoplasia in metastatic lymph node lesions is associated with lesion size and poor prognosis in pancreatic cancer patients

AU - Nakayama, Hiromichi

AU - Ohuchida, Kenoki

AU - Yoshida, Masaki

AU - Miyazaki, Tetsuyuki

AU - Takesue, Shin

AU - Abe, Toshiya

AU - Endo, Sho

AU - Koikawa, Kazuhiro

AU - Okumura, Takashi

AU - Moriyama, Taiki

AU - Nakata, Kohei

AU - Miyasaka, Yoshihiro

AU - Shirahane, Kengo

AU - Manabe, Tatsuya

AU - Ohtsuka, Takao

AU - Toma, Hiroki

AU - Tominaga, Yohei

AU - Nagai, Eishi

AU - Mizumoto, Kazuhiro

AU - Oda, Yoshinao

AU - Nakamura, Masafumi

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Pancreatic cancer is characterized by increased hyperplasia of fibrotic tissue, termed desmoplasia, and lymph node metastasis is an independent prognostic factor in this disease. However, there are no reports focused on desmoplasia in pancreatic cancer lymph node metastases. The present study evaluated a range of factors and investigated their association with poor prognosis in pancreatic cancer cases with lymph node metastasis, including the degree of desmoplasia in lesions. To identify the poor prognostic factors associated with lymph node metastasis, the present study retrospectively reviewed the clinical data of 65 patients with lymph node metastases that underwent surgical pancreatic cancer resection between 2007 and 2012 at a single institution. The investigation focused on the degree of fibrosis in metastatic lesions in 216 lymph nodes, and investigated associations with prognosis or clinicopathological findings. The ratios of the fibrotic area in metastatic lymph node lesions were evaluated and classified into three categories, high (≥70%), moderate (10-70%) and low (<10%). Desmoplasia was not observed in cancer-free lymph nodes. The size of metastatic lymph node lesions was additionally measured, and a significant association between metastatic lesion size and the degree of desmoplasia was observed (P<0.001). The degree of desmoplasia was additionally associated with local extranodal invasion. In the analysis of 65 pancreatic cancer patients with metastatic lymph nodes, the presence of multiple metastatic lymph nodes with moderate or high desmoplasia was significantly associated with poor survival (high, P=0.0048; moderate/high, P=0.0075). Of several clinicopathological factors, the presence of multiple metastatic lymph nodes with high or moderate desmoplasia was associated with overall survival in univariate (P=0.0098) and multivariate (P=0.0466) analyses. The degree of desmoplasia in metastatic lymph nodes is associated with lesion size, and the presence of multiple metastatic lymph nodes with desmoplasia is an independent poor prognostic factor, suggesting that the desmoplasia may have an important role in the malignant progression of lymph node metastases.

AB - Pancreatic cancer is characterized by increased hyperplasia of fibrotic tissue, termed desmoplasia, and lymph node metastasis is an independent prognostic factor in this disease. However, there are no reports focused on desmoplasia in pancreatic cancer lymph node metastases. The present study evaluated a range of factors and investigated their association with poor prognosis in pancreatic cancer cases with lymph node metastasis, including the degree of desmoplasia in lesions. To identify the poor prognostic factors associated with lymph node metastasis, the present study retrospectively reviewed the clinical data of 65 patients with lymph node metastases that underwent surgical pancreatic cancer resection between 2007 and 2012 at a single institution. The investigation focused on the degree of fibrosis in metastatic lesions in 216 lymph nodes, and investigated associations with prognosis or clinicopathological findings. The ratios of the fibrotic area in metastatic lymph node lesions were evaluated and classified into three categories, high (≥70%), moderate (10-70%) and low (<10%). Desmoplasia was not observed in cancer-free lymph nodes. The size of metastatic lymph node lesions was additionally measured, and a significant association between metastatic lesion size and the degree of desmoplasia was observed (P<0.001). The degree of desmoplasia was additionally associated with local extranodal invasion. In the analysis of 65 pancreatic cancer patients with metastatic lymph nodes, the presence of multiple metastatic lymph nodes with moderate or high desmoplasia was significantly associated with poor survival (high, P=0.0048; moderate/high, P=0.0075). Of several clinicopathological factors, the presence of multiple metastatic lymph nodes with high or moderate desmoplasia was associated with overall survival in univariate (P=0.0098) and multivariate (P=0.0466) analyses. The degree of desmoplasia in metastatic lymph nodes is associated with lesion size, and the presence of multiple metastatic lymph nodes with desmoplasia is an independent poor prognostic factor, suggesting that the desmoplasia may have an important role in the malignant progression of lymph node metastases.

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