Dehydroepiandrosterone attenuates the spontaneous elevation of serum IgE level in NC/Nga mice

N. Sudo, X. N. Yu, C. Kubo

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Dehydroepiandrosterone (DHEA) and its sulfate derivatives are known to affect host immune function; however if such hormones influence the development of atopic dermatitis has not yet been clarified. In this study, we examined the effects of DHEA on the allergic process using NC/Nga mouse, a model animal of human atopic dermatitis. The administration of DHEA profoundly suppressed the spontaneous elevation of both serum IgE and interleukin-6 levels in NC/Nga mice during the observation period. These results indicate that DHEA promotes a shift in Thl/Th2 balance toward Th1-dominant immunity, and thus may be one of the effective alternatives in treating atopic dermatitis.

Original languageEnglish
Pages (from-to)177-179
Number of pages3
JournalImmunology Letters
Volume79
Issue number3
DOIs
Publication statusPublished - Dec 3 2001

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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