Dehydroepiandrosterone attenuates the spontaneous elevation of serum IgE level in NC/Nga mice

N. Sudo, X. N. Yu, C. Kubo

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Dehydroepiandrosterone (DHEA) and its sulfate derivatives are known to affect host immune function; however if such hormones influence the development of atopic dermatitis has not yet been clarified. In this study, we examined the effects of DHEA on the allergic process using NC/Nga mouse, a model animal of human atopic dermatitis. The administration of DHEA profoundly suppressed the spontaneous elevation of both serum IgE and interleukin-6 levels in NC/Nga mice during the observation period. These results indicate that DHEA promotes a shift in Thl/Th2 balance toward Th1-dominant immunity, and thus may be one of the effective alternatives in treating atopic dermatitis.

Original languageEnglish
Pages (from-to)177-179
Number of pages3
JournalImmunology Letters
Volume79
Issue number3
DOIs
Publication statusPublished - Dec 3 2001

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Dehydroepiandrosterone
Atopic Dermatitis
Immunoglobulin E
Serum
Th1-Th2 Balance
Dehydroepiandrosterone Sulfate
Immunity
Interleukin-6
Animal Models
Observation
Hormones

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Dehydroepiandrosterone attenuates the spontaneous elevation of serum IgE level in NC/Nga mice. / Sudo, N.; Yu, X. N.; Kubo, C.

In: Immunology Letters, Vol. 79, No. 3, 03.12.2001, p. 177-179.

Research output: Contribution to journalArticle

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