Dehydroepiandrosterone(DHEA)and bone metabolism

Research output: Contribution to journalReview article

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Abstract

Dehydroepiandrosterone(DHEA), an adrenal androgen, has attracted much attention as an anti-aging hormone as well as a marker for senescence because of its unique change along with aging. DHEA is reported to have beneficial effects such as anti-diabetes, anti-obesity, and anti-atherosclerosis. It is also shown that DHEA has anti-osteoporosis effects to increase bone mineral density in randomized controlled trials(RCTs). As osteoblasts express aromatase which will convert androgen to estrogen, DHEA may act protectively against osteoporosis through its metabolites. Because there is no report on fracture risk by DHEA administration, further studies are required to clarify DHEA effects on human bone metabolism.

LanguageEnglish
Pages987-993
Number of pages7
JournalClinical calcium
Volume26
Issue number7
Publication statusPublished - Jul 1 2016

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Dehydroepiandrosterone
Bone and Bones
Androgens
Osteoporosis
Aromatase
Osteoblasts
Bone Density
Atherosclerosis
Estrogens
Randomized Controlled Trials
Obesity
Hormones

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Dehydroepiandrosterone(DHEA)and bone metabolism. / Keizo, Ohnaka.

In: Clinical calcium, Vol. 26, No. 7, 01.07.2016, p. 987-993.

Research output: Contribution to journalReview article

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