Delayed type skin response to myelin basic protein in chronic relapsing experimental allergic encephalomyelitis

Takeshi Tabira, Yasuto Itoyama, Yoshigoro Kuroiwa, Chiharu Kubo, Yoshitaka Nagai

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The skin response to myelin basic protein (MBP) was studied in chronic relapsing experimental allergic encephalomyelitis (EAE) using strain 13 guinea pigs. The delayed type skin response showed a monophasic curve; it gradually increased after immunization, reached maximum levels around 80 days post-immunization, and decreased thereafter. Relapses were more frequent while it was at high levels although it did not correlate directly in individuals with the clinical stage. The skin response was also high in MBP-immunized animals which had recovered from acute EAE. Our results suggest that delayed type hypersensitivity to MBP is involved but is not sufficient by itself to cause relapsing EAE.

Original languageEnglish
Pages (from-to)295-304
Number of pages10
JournalJournal of Neuroimmunology
Volume5
Issue number3
DOIs
Publication statusPublished - Dec 1983

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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