TY - JOUR
T1 - Delphinidin prevents disuse muscle atrophy and reduces stress-related gene expression
AU - Murata, Motoki
AU - Kosaka, Reia
AU - Kurihara, Kana
AU - Yamashita, Shuya
AU - Tachibana, Hirofumi
N1 - Funding Information:
This research was supported in part by Grants-in-Aid for Scientific Research (KAKENHI) from the Japan Society for the Promotion of Science to H.T. [grant number 22228002], [grant number 15H02448].
PY - 2016
Y1 - 2016
N2 - Delphinidin is a member of the anthocyanidin class of plant pigments. We examined the effects of delphinidin on muscle atrophy. Oral administration of delphinidin suppressed the muscle weight loss induced by mechanical unloading. Microarray analysis showed that delphinidin suppresses the upregulation of oxidative stress-related gene expression, including the expression of Cbl-b. Thus, delphinidin may prevent unloading-mediated muscle atrophy.
AB - Delphinidin is a member of the anthocyanidin class of plant pigments. We examined the effects of delphinidin on muscle atrophy. Oral administration of delphinidin suppressed the muscle weight loss induced by mechanical unloading. Microarray analysis showed that delphinidin suppresses the upregulation of oxidative stress-related gene expression, including the expression of Cbl-b. Thus, delphinidin may prevent unloading-mediated muscle atrophy.
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U2 - 10.1080/09168451.2016.1184560
DO - 10.1080/09168451.2016.1184560
M3 - Article
C2 - 27180787
AN - SCOPUS:84978933479
SN - 0916-8451
VL - 80
SP - 1636
EP - 1640
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 8
ER -