Delphinidin prevents muscle atrophy and upregulates MIR-23a expression

Motoki Murata, Haruna Nonaka, Satomi Komatsu, Megumi Goto, Mai Morozumi, Shuhei Yamada, I. Chian Lin, Shuya Yamashita, Hirofumi Tachibana

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

Delphinidin, one of the major anthocyanidins, shows protective effects against a variety of pathologies, including cancer, inflammation, and muscle atrophy. The purpose of this study was to determine the preventive mechanism of delphinidin on disuse muscle atrophy. In vitro and in vivo models were used to validate the effects of delphinidin on the expression of MuRF1, miR-23a, and NFATc3. Delphinidin suppressed the upregulation of MuRF1 (1.77 ± 0.05 vs 1.03 ± 0.17, P < 0.05) expression and inhibited the downregulation of miR-23a (0.56 ± 0.05 vs 0.94 ± 0.06, P < 0.05) and NFATc3 (0.61 ± 0.02 vs 1.02 ± 0.08, P < 0.01) expression in dexamethasone-treated C2C12 cells. In gastrocnemius, muscle weight loss was prevented by oral administration of delphinidin. Moreover, delphinidin suppressed MuRF1 (3.35 ± 0.13 vs 2.26 ± 0.3, P < 0.01) expression and promoted miR-23a (0.58 ± 0.15 vs 2.25 ± 0.29, P < 0.001) and NFATc3 (0.85 ± 0.17 vs 1.54 ± 0.13, P < 0.001) expressions. Delphinidin intake may prevent disuse muscle atrophy by inducing miR-23a expression and suppressing MuRF1 expression.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Volume65
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

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delphinidin
muscular atrophy
Muscular Atrophy
Muscle
Up-Regulation
Atrophic Muscular Disorders
Muscle Neoplasms
anthocyanidins
Anthocyanins
Pathology
dexamethasone
oral administration
Dexamethasone
protective effect
Oral Administration
Weight Loss

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

Cite this

Delphinidin prevents muscle atrophy and upregulates MIR-23a expression. / Murata, Motoki; Nonaka, Haruna; Komatsu, Satomi; Goto, Megumi; Morozumi, Mai; Yamada, Shuhei; Lin, I. Chian; Yamashita, Shuya; Tachibana, Hirofumi.

In: Journal of Agricultural and Food Chemistry, Vol. 65, No. 1, 01.01.2017, p. 45-50.

Research output: Contribution to journal › Article

Murata, M, Nonaka, H, Komatsu, S, Goto, M, Morozumi, M, Yamada, S, Lin, IC, Yamashita, S & Tachibana, H 2017, 'Delphinidin prevents muscle atrophy and upregulates MIR-23a expression', Journal of Agricultural and Food Chemistry, vol. 65, no. 1, pp. 45-50. https://doi.org/10.1021/acs.jafc.6b03661
Murata M, Nonaka H, Komatsu S, Goto M, Morozumi M, Yamada S et al. Delphinidin prevents muscle atrophy and upregulates MIR-23a expression. Journal of Agricultural and Food Chemistry. 2017 Jan 1;65(1):45-50. https://doi.org/10.1021/acs.jafc.6b03661
Murata, Motoki ; Nonaka, Haruna ; Komatsu, Satomi ; Goto, Megumi ; Morozumi, Mai ; Yamada, Shuhei ; Lin, I. Chian ; Yamashita, Shuya ; Tachibana, Hirofumi. / Delphinidin prevents muscle atrophy and upregulates MIR-23a expression. In: Journal of Agricultural and Food Chemistry. 2017 ; Vol. 65, No. 1. pp. 45-50.
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AU - Tachibana, Hirofumi

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AB - Delphinidin, one of the major anthocyanidins, shows protective effects against a variety of pathologies, including cancer, inflammation, and muscle atrophy. The purpose of this study was to determine the preventive mechanism of delphinidin on disuse muscle atrophy. In vitro and in vivo models were used to validate the effects of delphinidin on the expression of MuRF1, miR-23a, and NFATc3. Delphinidin suppressed the upregulation of MuRF1 (1.77 ± 0.05 vs 1.03 ± 0.17, P < 0.05) expression and inhibited the downregulation of miR-23a (0.56 ± 0.05 vs 0.94 ± 0.06, P < 0.05) and NFATc3 (0.61 ± 0.02 vs 1.02 ± 0.08, P < 0.01) expression in dexamethasone-treated C2C12 cells. In gastrocnemius, muscle weight loss was prevented by oral administration of delphinidin. Moreover, delphinidin suppressed MuRF1 (3.35 ± 0.13 vs 2.26 ± 0.3, P < 0.01) expression and promoted miR-23a (0.58 ± 0.15 vs 2.25 ± 0.29, P < 0.001) and NFATc3 (0.85 ± 0.17 vs 1.54 ± 0.13, P < 0.001) expressions. Delphinidin intake may prevent disuse muscle atrophy by inducing miR-23a expression and suppressing MuRF1 expression.

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