The present article introduces studies related to catalepsy-like immobilization induced by delta-9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana. THC induces catalepsy-like immobilization, and this behavior is antagonized by the cannabinoid (CB)1 receptor antagonist rimonabant. Also, the microinjection of THC into the nucleus accumbens induces catalepsy-like immobilization, and THC-induced catalepsy-like immobilization is prevented by lesions in the nucleus accumbens. 5-Hydroxytryptamine (5-HT) receptor agonists inhibit THC-induced catalepsy-like immobilization. In contrast, 5-HT receptor antagonists enhance THC-induced catalepsy-like immobilization. THC-induced catalepsy-like immobilization is also prevented by MK-801 and amantadine. THC decreased extracellular 5-HT levels in rat nucleus accumbens, and this effect was antagonized by rimonabant. Moreover, MK-801 abolished this THC-induced decrease in 5-HT releases. Taken together, these results demonstrate that CB1-mediated, THC-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens, due to the action of glutamate-containing neurons.
|Title of host publication||Handbook of Cannabis and Related Pathologies|
|Subtitle of host publication||Biology, Pharmacology, Diagnosis, and Treatment|
|Number of pages||9|
|Publication status||Published - Jan 24 2017|
All Science Journal Classification (ASJC) codes