Delta-9-Tetrahydrocannabinol and Catalepsy-Like Immobilization

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Abstract

The present article introduces studies related to catalepsy-like immobilization induced by delta-9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana. THC induces catalepsy-like immobilization, and this behavior is antagonized by the cannabinoid (CB)1 receptor antagonist rimonabant. Also, the microinjection of THC into the nucleus accumbens induces catalepsy-like immobilization, and THC-induced catalepsy-like immobilization is prevented by lesions in the nucleus accumbens. 5-Hydroxytryptamine (5-HT) receptor agonists inhibit THC-induced catalepsy-like immobilization. In contrast, 5-HT receptor antagonists enhance THC-induced catalepsy-like immobilization. THC-induced catalepsy-like immobilization is also prevented by MK-801 and amantadine. THC decreased extracellular 5-HT levels in rat nucleus accumbens, and this effect was antagonized by rimonabant. Moreover, MK-801 abolished this THC-induced decrease in 5-HT releases. Taken together, these results demonstrate that CB1-mediated, THC-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens, due to the action of glutamate-containing neurons.

Original languageEnglish
Title of host publicationHandbook of Cannabis and Related Pathologies
Subtitle of host publicationBiology, Pharmacology, Diagnosis, and Treatment
PublisherElsevier Inc.
Pages326-334
Number of pages9
ISBN (Electronic)9780128008270
ISBN (Print)9780128007563
DOIs
Publication statusPublished - Jan 24 2017

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

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  • Cite this

    Egashira, N. (2017). Delta-9-Tetrahydrocannabinol and Catalepsy-Like Immobilization. In Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment (pp. 326-334). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800756-3.00038-7