Delta-9-Tetrahydrocannabinol and Catalepsy-Like Immobilization

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The present article introduces studies related to catalepsy-like immobilization induced by delta-9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana. THC induces catalepsy-like immobilization, and this behavior is antagonized by the cannabinoid (CB)1 receptor antagonist rimonabant. Also, the microinjection of THC into the nucleus accumbens induces catalepsy-like immobilization, and THC-induced catalepsy-like immobilization is prevented by lesions in the nucleus accumbens. 5-Hydroxytryptamine (5-HT) receptor agonists inhibit THC-induced catalepsy-like immobilization. In contrast, 5-HT receptor antagonists enhance THC-induced catalepsy-like immobilization. THC-induced catalepsy-like immobilization is also prevented by MK-801 and amantadine. THC decreased extracellular 5-HT levels in rat nucleus accumbens, and this effect was antagonized by rimonabant. Moreover, MK-801 abolished this THC-induced decrease in 5-HT releases. Taken together, these results demonstrate that CB1-mediated, THC-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens, due to the action of glutamate-containing neurons.

Original languageEnglish
Title of host publicationHandbook of Cannabis and Related Pathologies
Subtitle of host publicationBiology, Pharmacology, Diagnosis, and Treatment
PublisherElsevier Inc.
Pages326-334
Number of pages9
ISBN (Electronic)9780128008270
ISBN (Print)9780128007563
DOIs
Publication statusPublished - Jan 24 2017

Fingerprint

Catalepsy
Dronabinol
Immobilization
rimonabant
Nucleus Accumbens
Serotonin
Dizocilpine Maleate
Serotonin Receptors
Cannabinoid Receptor Antagonists
Amantadine
Serotonin Receptor Agonists
Serotonin Antagonists
Microinjections
Cannabis
Synaptic Transmission
Glutamic Acid

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

Cite this

Egashira, N. (2017). Delta-9-Tetrahydrocannabinol and Catalepsy-Like Immobilization. In Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment (pp. 326-334). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800756-3.00038-7

Delta-9-Tetrahydrocannabinol and Catalepsy-Like Immobilization. / Egashira, Nobuaki.

Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment. Elsevier Inc., 2017. p. 326-334.

Research output: Chapter in Book/Report/Conference proceedingChapter

Egashira, N 2017, Delta-9-Tetrahydrocannabinol and Catalepsy-Like Immobilization. in Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment. Elsevier Inc., pp. 326-334. https://doi.org/10.1016/B978-0-12-800756-3.00038-7
Egashira N. Delta-9-Tetrahydrocannabinol and Catalepsy-Like Immobilization. In Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment. Elsevier Inc. 2017. p. 326-334 https://doi.org/10.1016/B978-0-12-800756-3.00038-7
Egashira, Nobuaki. / Delta-9-Tetrahydrocannabinol and Catalepsy-Like Immobilization. Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment. Elsevier Inc., 2017. pp. 326-334
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