Abstract
The present article introduces studies related to catalepsy-like immobilization induced by delta-9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana. THC induces catalepsy-like immobilization, and this behavior is antagonized by the cannabinoid (CB)1 receptor antagonist rimonabant. Also, the microinjection of THC into the nucleus accumbens induces catalepsy-like immobilization, and THC-induced catalepsy-like immobilization is prevented by lesions in the nucleus accumbens. 5-Hydroxytryptamine (5-HT) receptor agonists inhibit THC-induced catalepsy-like immobilization. In contrast, 5-HT receptor antagonists enhance THC-induced catalepsy-like immobilization. THC-induced catalepsy-like immobilization is also prevented by MK-801 and amantadine. THC decreased extracellular 5-HT levels in rat nucleus accumbens, and this effect was antagonized by rimonabant. Moreover, MK-801 abolished this THC-induced decrease in 5-HT releases. Taken together, these results demonstrate that CB1-mediated, THC-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens, due to the action of glutamate-containing neurons.
| Original language | English |
|---|---|
| Title of host publication | Handbook of Cannabis and Related Pathologies |
| Subtitle of host publication | Biology, Pharmacology, Diagnosis, and Treatment |
| Publisher | Elsevier Inc. |
| Pages | 326-334 |
| Number of pages | 9 |
| ISBN (Electronic) | 9780128008270 |
| ISBN (Print) | 9780128007563 |
| DOIs | |
| Publication status | Published - Jan 24 2017 |
All Science Journal Classification (ASJC) codes
- Medicine(all)
- Neuroscience(all)