Dendritic cell development from common myeloid progenitors

Markus G. Manz, David Traver, Koichi Akashi, Miriam Merad, Toshihiro Miyamoto, Edgar G. Engleman, Irving L. Weissman

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)


Dendritic cells (DCs) are professional antigen-presenting cells which both initiate adaptive immune responses and control tolerance to self-antigens. It has been suggested that these different effects on responder cells depend on subsets of DCs arising from either myeioid or lymphoid hematopoietic origins. In this model, CD8α+ Mac-1- DCs are supposed to be of lymphoid while CD8α- Mac-1+ DCs are supposed to be of myeioid origin. Here we summarize our findings that both CD8α+ and CD8α- DCs can arise from clonogenic common myeloid progenitors (CMPs) in both thymus and spleen. Therefore CD8α expression on DCs does not indicate a lymphoid origin and differences among CD8α+ and CD8α- DCs might rather reflect maturation status than ontogeny. On the basis of transplantation studies, it seems likely that most of the DCs in secondary lymphoid organs and a substantial fraction of thymic DCs are myeloid-derived.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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