Abstract
Dendritic cells (DCs) are professional antigen-presenting cells which both initiate adaptive immune responses and control tolerance to self-antigens. It has been suggested that these different effects on responder cells depend on subsets of DCs arising from either myeioid or lymphoid hematopoietic origins. In this model, CD8α+ Mac-1- DCs are supposed to be of lymphoid while CD8α- Mac-1+ DCs are supposed to be of myeioid origin. Here we summarize our findings that both CD8α+ and CD8α- DCs can arise from clonogenic common myeloid progenitors (CMPs) in both thymus and spleen. Therefore CD8α expression on DCs does not indicate a lymphoid origin and differences among CD8α+ and CD8α- DCs might rather reflect maturation status than ontogeny. On the basis of transplantation studies, it seems likely that most of the DCs in secondary lymphoid organs and a substantial fraction of thymic DCs are myeloid-derived.
| Original language | English |
|---|---|
| Pages (from-to) | 167-174 |
| Number of pages | 8 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 938 |
| Publication status | Published - Jan 1 2001 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
Cite this
Dendritic cell development from common myeloid progenitors. / Manz, Markus G.; Traver, David; Akashi, Koichi; Merad, Miriam; Miyamoto, Toshihiro; Engleman, Edgar G.; Weissman, Irving L.
In: Annals of the New York Academy of Sciences, Vol. 938, 01.01.2001, p. 167-174.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dendritic cell development from common myeloid progenitors
AU - Manz, Markus G.
AU - Traver, David
AU - Akashi, Koichi
AU - Merad, Miriam
AU - Miyamoto, Toshihiro
AU - Engleman, Edgar G.
AU - Weissman, Irving L.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Dendritic cells (DCs) are professional antigen-presenting cells which both initiate adaptive immune responses and control tolerance to self-antigens. It has been suggested that these different effects on responder cells depend on subsets of DCs arising from either myeioid or lymphoid hematopoietic origins. In this model, CD8α+ Mac-1- DCs are supposed to be of lymphoid while CD8α- Mac-1+ DCs are supposed to be of myeioid origin. Here we summarize our findings that both CD8α+ and CD8α- DCs can arise from clonogenic common myeloid progenitors (CMPs) in both thymus and spleen. Therefore CD8α expression on DCs does not indicate a lymphoid origin and differences among CD8α+ and CD8α- DCs might rather reflect maturation status than ontogeny. On the basis of transplantation studies, it seems likely that most of the DCs in secondary lymphoid organs and a substantial fraction of thymic DCs are myeloid-derived.
AB - Dendritic cells (DCs) are professional antigen-presenting cells which both initiate adaptive immune responses and control tolerance to self-antigens. It has been suggested that these different effects on responder cells depend on subsets of DCs arising from either myeioid or lymphoid hematopoietic origins. In this model, CD8α+ Mac-1- DCs are supposed to be of lymphoid while CD8α- Mac-1+ DCs are supposed to be of myeioid origin. Here we summarize our findings that both CD8α+ and CD8α- DCs can arise from clonogenic common myeloid progenitors (CMPs) in both thymus and spleen. Therefore CD8α expression on DCs does not indicate a lymphoid origin and differences among CD8α+ and CD8α- DCs might rather reflect maturation status than ontogeny. On the basis of transplantation studies, it seems likely that most of the DCs in secondary lymphoid organs and a substantial fraction of thymic DCs are myeloid-derived.
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M3 - Article
C2 - 11458504
AN - SCOPUS:0034937916
VL - 938
SP - 167
EP - 174
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -