Dendritic cells (DCs) are professional antigen-presenting cells which both initiate adaptive immune responses and control tolerance to self-antigens. It has been suggested that these different effects on responder cells depend on subsets of DCs arising from either myeioid or lymphoid hematopoietic origins. In this model, CD8α+ Mac-1- DCs are supposed to be of lymphoid while CD8α- Mac-1+ DCs are supposed to be of myeioid origin. Here we summarize our findings that both CD8α+ and CD8α- DCs can arise from clonogenic common myeloid progenitors (CMPs) in both thymus and spleen. Therefore CD8α expression on DCs does not indicate a lymphoid origin and differences among CD8α+ and CD8α- DCs might rather reflect maturation status than ontogeny. On the basis of transplantation studies, it seems likely that most of the DCs in secondary lymphoid organs and a substantial fraction of thymic DCs are myeloid-derived.
|Number of pages||8|
|Journal||Annals of the New York Academy of Sciences|
|Publication status||Published - Jan 1 2001|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science