Dendritic cell development from common myeloid progenitors

Markus G. Manz, David Traver, Koichi Akashi, Miriam Merad, Toshihiro Miyamoto, Edgar G. Engleman, Irving L. Weissman

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Dendritic cells (DCs) are professional antigen-presenting cells which both initiate adaptive immune responses and control tolerance to self-antigens. It has been suggested that these different effects on responder cells depend on subsets of DCs arising from either myeioid or lymphoid hematopoietic origins. In this model, CD8α+ Mac-1- DCs are supposed to be of lymphoid while CD8α- Mac-1+ DCs are supposed to be of myeioid origin. Here we summarize our findings that both CD8α+ and CD8α- DCs can arise from clonogenic common myeloid progenitors (CMPs) in both thymus and spleen. Therefore CD8α expression on DCs does not indicate a lymphoid origin and differences among CD8α+ and CD8α- DCs might rather reflect maturation status than ontogeny. On the basis of transplantation studies, it seems likely that most of the DCs in secondary lymphoid organs and a substantial fraction of thymic DCs are myeloid-derived.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume938
Publication statusPublished - Jan 1 2001
Externally publishedYes

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Myeloid Progenitor Cells
Dendritic Cells
Cells
Thymus
Autoantigens
Adaptive Immunity
Antigen-Presenting Cells
Thymus Gland
Spleen
Transplantation

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Manz, M. G., Traver, D., Akashi, K., Merad, M., Miyamoto, T., Engleman, E. G., & Weissman, I. L. (2001). Dendritic cell development from common myeloid progenitors. Annals of the New York Academy of Sciences, 938, 167-174.

Dendritic cell development from common myeloid progenitors. / Manz, Markus G.; Traver, David; Akashi, Koichi; Merad, Miriam; Miyamoto, Toshihiro; Engleman, Edgar G.; Weissman, Irving L.

In: Annals of the New York Academy of Sciences, Vol. 938, 01.01.2001, p. 167-174.

Research output: Contribution to journalArticle

Manz, MG, Traver, D, Akashi, K, Merad, M, Miyamoto, T, Engleman, EG & Weissman, IL 2001, 'Dendritic cell development from common myeloid progenitors', Annals of the New York Academy of Sciences, vol. 938, pp. 167-174.
Manz, Markus G. ; Traver, David ; Akashi, Koichi ; Merad, Miriam ; Miyamoto, Toshihiro ; Engleman, Edgar G. ; Weissman, Irving L. / Dendritic cell development from common myeloid progenitors. In: Annals of the New York Academy of Sciences. 2001 ; Vol. 938. pp. 167-174.
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