Depth-dependent compressive behaviors of articular cartilage and chondrocytes

T. Murakami, N. Sakai, Yoshinori Sawae, M. Okamoto, I. Ishikawa, N. Hosoda, E. Suzuki

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

The natural synovial joints have excellent performance of long durability with low friction even under high load. To study metabolic mechanism in articular cartilage containing chondrocytes, it is important to know the actual structure and stress-strain state of the cartilage and extracellular matrix around chondrocytes during cartilage deformation, where chondrocytes seem to experience similar deformation to extracellular matrix. The articular cartilage of high water content has a biphasic viscoelastic property and shows the timedependent and depth-dependent deformation behavior. In this study, the morphology of chondrocyte was visualized, and the compressive behaviors in articular cartilage containing chondrocytes were observed in the compressive apparatus located in the stage of confocal laser scanning microscope. The time-dependent and depth-dependent behaviors of articular cartilage were evaluated by the finite element method for biphasic model.

Original languageEnglish
Title of host publicationBiomechanics at Micro- and Nanoscale Levels
PublisherWorld Scientific Publishing Co.
Pages36-46
Number of pages11
ISBN (Electronic)9789812771322
ISBN (Print)981277131X, 9789812771315
DOIs
Publication statusPublished - Jan 1 2007

Fingerprint

Cartilage
Articular Cartilage
Chondrocytes
Extracellular Matrix
Friction
Lasers
Water content
Joints
Loads (forces)
Durability
Microscopes
Water
Scanning
Finite element method

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Murakami, T., Sakai, N., Sawae, Y., Okamoto, M., Ishikawa, I., Hosoda, N., & Suzuki, E. (2007). Depth-dependent compressive behaviors of articular cartilage and chondrocytes. In Biomechanics at Micro- and Nanoscale Levels (pp. 36-46). World Scientific Publishing Co.. https://doi.org/10.1142/9789812771322_0004

Depth-dependent compressive behaviors of articular cartilage and chondrocytes. / Murakami, T.; Sakai, N.; Sawae, Yoshinori; Okamoto, M.; Ishikawa, I.; Hosoda, N.; Suzuki, E.

Biomechanics at Micro- and Nanoscale Levels. World Scientific Publishing Co., 2007. p. 36-46.

Research output: Chapter in Book/Report/Conference proceedingChapter

Murakami, T, Sakai, N, Sawae, Y, Okamoto, M, Ishikawa, I, Hosoda, N & Suzuki, E 2007, Depth-dependent compressive behaviors of articular cartilage and chondrocytes. in Biomechanics at Micro- and Nanoscale Levels. World Scientific Publishing Co., pp. 36-46. https://doi.org/10.1142/9789812771322_0004
Murakami T, Sakai N, Sawae Y, Okamoto M, Ishikawa I, Hosoda N et al. Depth-dependent compressive behaviors of articular cartilage and chondrocytes. In Biomechanics at Micro- and Nanoscale Levels. World Scientific Publishing Co. 2007. p. 36-46 https://doi.org/10.1142/9789812771322_0004
Murakami, T. ; Sakai, N. ; Sawae, Yoshinori ; Okamoto, M. ; Ishikawa, I. ; Hosoda, N. ; Suzuki, E. / Depth-dependent compressive behaviors of articular cartilage and chondrocytes. Biomechanics at Micro- and Nanoscale Levels. World Scientific Publishing Co., 2007. pp. 36-46
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