Dermatomyositis complicated with asymmetric peripheral neuritis on exacerbation: A case report and literature review

Takashi Irie, Hiroshi Shigeto, Junpei Koge, Hiroo Yamaguchi, Hiroyuki Murai, Jun Ichi Kira

Research output: Contribution to journalArticle

Abstract

We describe a 69-year-old woman with dermatomyositis who presented with asymmetric peripheral neuritis. The patient first developed dermatomyositis at 39 years-of-age; her symptoms improved several years later with oral prednisolone treatment. A year and a half before admission to our hospital, she developed a sensory disturbance in her feet that gradually expanded to both legs with left dominance. Six months later, bilateral leg muscle weakness and proximal muscle tenderness appeared. Neurological examination at admission revealed proximal muscle weakness and atrophy of all four limbs. Ankle jerk was absent bilaterally. There was sensory impairment in the left hand and both lower limbs, with more severe involvement of the left side and the medial side. Electrophysiological tests showed decreased sensory nerve action potentials in the left superficial fibular nerve and bilateral sural nerves, and decreased motor action potentials in the bilateral fibular nerves. We diagnosed mononeuritis multiplex as a complication of dermatomyositis. Her symptoms of mononeuritis multiplex and dermatomyositis were successfully treated with intravenous methylprednisolone pulse therapy followed by oral prednisolone therapy. Although our literature search found nine cases of dermatomyositis with polyneuropathy/polyradiculoneuropathy, most of which involved axonal neuropathy, this is the first case report of dermatomyositis presenting with mononeuritis multiplex.

Original languageEnglish
Pages (from-to)373-380
Number of pages8
JournalClinical and Experimental Neuroimmunology
Volume7
Issue number4
DOIs
Publication statusPublished - Nov 1 2016

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Neuritis
Dermatomyositis
Mononeuropathies
Peroneal Nerve
Muscle Weakness
Prednisolone
Action Potentials
Leg
Polyradiculoneuropathy
Sural Nerve
Muscular Atrophy
Polyneuropathies
Myalgia
Methylprednisolone
Neurologic Examination
Ankle
Foot
Lower Extremity
Therapeutics
Extremities

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Immunology
  • Immunology and Microbiology (miscellaneous)
  • Clinical Neurology

Cite this

Dermatomyositis complicated with asymmetric peripheral neuritis on exacerbation : A case report and literature review. / Irie, Takashi; Shigeto, Hiroshi; Koge, Junpei; Yamaguchi, Hiroo; Murai, Hiroyuki; Kira, Jun Ichi.

In: Clinical and Experimental Neuroimmunology, Vol. 7, No. 4, 01.11.2016, p. 373-380.

Research output: Contribution to journalArticle

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