Design and synthesis of an α-mannosyl terpenoid as selective inhibitor of P-selectin

Tsuyoshi Ikeda, Tetsuya Kajimoto, Hirosato Kondo, Chi Huey Wong

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In an effort to develop the structural and functional mimics of the tetrasaccharide sialyl Lewis x as selective inhibitors of P-selectin, we have designed a mannosyl terpenoid derivative that selectively inhibits P-selectin within an IC50 value of 60 μM, but exhibits no inhibition activity against E- and L-selectins.

Original languageEnglish
Pages (from-to)2485-2490
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number19
DOIs
Publication statusPublished - Oct 7 1997
Externally publishedYes

Fingerprint

P-Selectin
Terpenes
L-Selectin
E-Selectin
Inhibitory Concentration 50
Derivatives
5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Design and synthesis of an α-mannosyl terpenoid as selective inhibitor of P-selectin. / Ikeda, Tsuyoshi; Kajimoto, Tetsuya; Kondo, Hirosato; Wong, Chi Huey.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 19, 07.10.1997, p. 2485-2490.

Research output: Contribution to journalArticle

Ikeda, Tsuyoshi ; Kajimoto, Tetsuya ; Kondo, Hirosato ; Wong, Chi Huey. / Design and synthesis of an α-mannosyl terpenoid as selective inhibitor of P-selectin. In: Bioorganic and Medicinal Chemistry Letters. 1997 ; Vol. 7, No. 19. pp. 2485-2490.
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