Design and synthesis of an α-mannosyl terpenoid as selective inhibitor of P-selectin

Tsuyoshi Ikeda, Tetsuya Kajimoto, Hirosato Kondo, Chi Huey Wong

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In an effort to develop the structural and functional mimics of the tetrasaccharide sialyl Lewis x as selective inhibitors of P-selectin, we have designed a mannosyl terpenoid derivative that selectively inhibits P-selectin within an IC50 value of 60 μM, but exhibits no inhibition activity against E- and L-selectins.

Original languageEnglish
Pages (from-to)2485-2490
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number19
DOIs
Publication statusPublished - Oct 7 1997

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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