Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin

Minoru Yamamoto, Shoji Ikeda, Hirosato Kondo, Shintaro Inoue

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The first example of dual inhibitors for matrix metalloproteinase (MMP) and cathepsin is described. An appropriate alignment of peptide-parts and two different specific functional groups in one molecule led to the discovery of a potent dual inhibitor (3a).

Original languageEnglish
Pages (from-to)375-378
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number3
DOIs
Publication statusPublished - Feb 11 2002
Externally publishedYes

Fingerprint

Cathepsins
Matrix Metalloproteinase Inhibitors
Functional groups
Peptides
Molecules

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin. / Yamamoto, Minoru; Ikeda, Shoji; Kondo, Hirosato; Inoue, Shintaro.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 12, No. 3, 11.02.2002, p. 375-378.

Research output: Contribution to journalArticle

Yamamoto, Minoru ; Ikeda, Shoji ; Kondo, Hirosato ; Inoue, Shintaro. / Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin. In: Bioorganic and Medicinal Chemistry Letters. 2002 ; Vol. 12, No. 3. pp. 375-378.
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