Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin

Minoru Yamamoto, Shoji Ikeda, Hirosato Kondo, Shintaro Inoue

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The first example of dual inhibitors for matrix metalloproteinase (MMP) and cathepsin is described. An appropriate alignment of peptide-parts and two different specific functional groups in one molecule led to the discovery of a potent dual inhibitor (3a).

Original languageEnglish
Pages (from-to)375-378
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number3
DOIs
Publication statusPublished - Feb 11 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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