Design and synthesis of protein kinase Cα activators based on 'out of pocket' interactions

Go Hirai; Megumi Ohkubo; Yuki Tamura; Mikiko Sodeoka

doi:10.1016/j.bmcl.2011.04.108

Design and synthesis of protein kinase Cα activators based on 'out of pocket' interactions

Go Hirai, Megumi Ohkubo, Yuki Tamura, Mikiko Sodeoka

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Novel types of PKCα activators based on isobenzofuranone bearing a myo-inositol moiety were designed and synthesized. The derivatives with bulky substituents on the myo-inositol moiety significantly activated PKCα, but their binding sites were not the same as that of phorbol ester.

Original language	English
Pages (from-to)	3587-3590
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2011.04.108
Publication status	Published - Jun 15 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2011.04.108

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abstract = "Novel types of PKCα activators based on isobenzofuranone bearing a myo-inositol moiety were designed and synthesized. The derivatives with bulky substituents on the myo-inositol moiety significantly activated PKCα, but their binding sites were not the same as that of phorbol ester.",

author = "Go Hirai and Megumi Ohkubo and Yuki Tamura and Mikiko Sodeoka",

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AU - Ohkubo, Megumi

AU - Tamura, Yuki

AU - Sodeoka, Mikiko

PY - 2011/6/15

Y1 - 2011/6/15

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AB - Novel types of PKCα activators based on isobenzofuranone bearing a myo-inositol moiety were designed and synthesized. The derivatives with bulky substituents on the myo-inositol moiety significantly activated PKCα, but their binding sites were not the same as that of phorbol ester.

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ER -

Design and synthesis of protein kinase Cα activators based on 'out of pocket' interactions

Abstract

All Science Journal Classification (ASJC) codes

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