Design and synthesis of protein kinase Cα activators based on 'out of pocket' interactions

Go Hirai, Megumi Ohkubo, Yuki Tamura, Mikiko Sodeoka

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Novel types of PKCα activators based on isobenzofuranone bearing a myo-inositol moiety were designed and synthesized. The derivatives with bulky substituents on the myo-inositol moiety significantly activated PKCα, but their binding sites were not the same as that of phorbol ester.

Original languageEnglish
Pages (from-to)3587-3590
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number12
DOIs
Publication statusPublished - Jun 15 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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