Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the5mCG base pair

Ryotaro Notomi, Lei Wang, Shigeki Sasaki, Yosuke Taniguchi

Research output: Contribution to journalArticlepeer-review

Abstract

We herein demonstrated for the first time the direct recognition of duplex DNA bearing the 5-methyl-2′-deoxycytosine and 2′-deoxyguanosine base pair by triplex DNA formation. Triplex-forming oligonucleotides contained the novel artificial nucleoside analogues 2-amino-2′-deoxy-nebularine derivatives, and their molecular design, synthesis, and functional evaluation are described.

Original languageEnglish
Pages (from-to)21390-21396
Number of pages7
JournalRSC Advances
Volume11
Issue number35
DOIs
Publication statusPublished - Jun 16 2021

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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