Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [ 15 N, D 14 ]trimethylphenylammonium (TMPA) has a remarkably long spin-lattice relaxation time (1128 s, 14.1 T, 30 °C, D 2 O) on its 15 N nuclei and achieves a long retention of the hyperpolarized state. [ 15 N, D 14 ]TMPA-based hyperpolarized sensor for carboxylesterase allowed the highly sensitive analysis of enzymatic reaction by 15 N NMR for over 40 min in phophate-buffered saline (H 2 O, pH 7.4, 37 °C).
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