Design of a 15 N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State

Hiroshi Nonaka; Masashi Hirano; Yuki Imakura; Yoichi Takakusagi; Kazuhiro Ichikawa; Shinsuke Sando

doi:10.1038/srep40104

Design of a 15 N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State

Hiroshi Nonaka, Masashi Hirano, Yuki Imakura, Yoichi Takakusagi, Kazuhiro Ichikawa, Shinsuke Sando

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30 Citations (Scopus)

Abstract

Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [ 15 N, D 14 ]trimethylphenylammonium (TMPA) has a remarkably long spin-lattice relaxation time (1128 s, 14.1 T, 30 °C, D 2 O) on its 15 N nuclei and achieves a long retention of the hyperpolarized state. [ 15 N, D 14 ]TMPA-based hyperpolarized sensor for carboxylesterase allowed the highly sensitive analysis of enzymatic reaction by 15 N NMR for over 40 min in phophate-buffered saline (H 2 O, pH 7.4, 37 °C).

Original language	English
Article number	40104
Journal	Scientific reports
Volume	7
DOIs	https://doi.org/10.1038/srep40104
Publication status	Published - Jan 9 2017

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title = "Design of a 15 N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State",

abstract = "Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [ 15 N, D 14 ]trimethylphenylammonium (TMPA) has a remarkably long spin-lattice relaxation time (1128 s, 14.1 T, 30 °C, D 2 O) on its 15 N nuclei and achieves a long retention of the hyperpolarized state. [ 15 N, D 14 ]TMPA-based hyperpolarized sensor for carboxylesterase allowed the highly sensitive analysis of enzymatic reaction by 15 N NMR for over 40 min in phophate-buffered saline (H 2 O, pH 7.4, 37 °C).",

author = "Hiroshi Nonaka and Masashi Hirano and Yuki Imakura and Yoichi Takakusagi and Kazuhiro Ichikawa and Shinsuke Sando",

note = "Funding Information: This work was supported by CREST, Japan Science and Technology Agency (JST). The use of HyperSense was in part supported by the funding program Creation of Innovation Centers for Advanced Interdisciplinary Research Areas from JST. Publisher Copyright: {\textcopyright} The Author(s) 2017.",

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T1 - Design of a 15 N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State

AU - Nonaka, Hiroshi

AU - Hirano, Masashi

AU - Imakura, Yuki

AU - Takakusagi, Yoichi

AU - Ichikawa, Kazuhiro

AU - Sando, Shinsuke

N1 - Funding Information: This work was supported by CREST, Japan Science and Technology Agency (JST). The use of HyperSense was in part supported by the funding program Creation of Innovation Centers for Advanced Interdisciplinary Research Areas from JST. Publisher Copyright: © The Author(s) 2017.

PY - 2017/1/9

Y1 - 2017/1/9

N2 - Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [ 15 N, D 14 ]trimethylphenylammonium (TMPA) has a remarkably long spin-lattice relaxation time (1128 s, 14.1 T, 30 °C, D 2 O) on its 15 N nuclei and achieves a long retention of the hyperpolarized state. [ 15 N, D 14 ]TMPA-based hyperpolarized sensor for carboxylesterase allowed the highly sensitive analysis of enzymatic reaction by 15 N NMR for over 40 min in phophate-buffered saline (H 2 O, pH 7.4, 37 °C).

AB - Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [ 15 N, D 14 ]trimethylphenylammonium (TMPA) has a remarkably long spin-lattice relaxation time (1128 s, 14.1 T, 30 °C, D 2 O) on its 15 N nuclei and achieves a long retention of the hyperpolarized state. [ 15 N, D 14 ]TMPA-based hyperpolarized sensor for carboxylesterase allowed the highly sensitive analysis of enzymatic reaction by 15 N NMR for over 40 min in phophate-buffered saline (H 2 O, pH 7.4, 37 °C).

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Design of a 15 N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State

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