Design of a 15 N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State

Hiroshi Nonaka, Masashi Hirano, Yuki Imakura, Yoichi Takakusagi, Kazuhiro Ichikawa, Shinsuke Sando

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    Abstract

    Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [ 15 N, D 14 ]trimethylphenylammonium (TMPA) has a remarkably long spin-lattice relaxation time (1128 s, 14.1 T, 30 °C, D 2 O) on its 15 N nuclei and achieves a long retention of the hyperpolarized state. [ 15 N, D 14 ]TMPA-based hyperpolarized sensor for carboxylesterase allowed the highly sensitive analysis of enzymatic reaction by 15 N NMR for over 40 min in phophate-buffered saline (H 2 O, pH 7.4, 37 °C).

    Original languageEnglish
    Article number40104
    JournalScientific reports
    Volume7
    DOIs
    Publication statusPublished - Jan 9 2017

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    All Science Journal Classification (ASJC) codes

    • General

    Cite this

    Nonaka, H., Hirano, M., Imakura, Y., Takakusagi, Y., Ichikawa, K., & Sando, S. (2017). Design of a 15 N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State. Scientific reports, 7, [40104]. https://doi.org/10.1038/srep40104