Design of a Bioinert Interface Using an Amphiphilic Block Copolymer Containing a Bottlebrush Unit of Oligo(oxazoline)

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2 Citations (Scopus)

Abstract

We designed an amphiphilic block copolymer, poly(methyl methacrylate)-block-poly[oligo(2-ethyl-2-oxazoline) methacrylate] (PMMA-b-P[O(Ox)MA]), suitable for bioinert coating. Angular-dependent X-ray photoelectron spectroscopy and neutron reflectivity measurements revealed that the outermost surface of a dried film of PMMA-b-P[O(Ox)MA] was covered with the PMMA block-rich layer. Once the film came into contact with water, the P[O(Ox)MA] bottlebrush block was segregated toward the water interface. This structural rearrangement in the outermost region of the film resulted in the formation of the swollen oligo(oxazoline) layer with excellent bioinertness in terms of the suppression of serum protein adsorption and NIH3T3 fibroblast adhesion.

Original languageEnglish
JournalACS Applied Bio Materials
DOIs
Publication statusAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Chemistry(all)
  • Biomedical Engineering
  • Biochemistry, medical

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