Design of a lipid bilayer electrical device. Strong chemical structure dependence and molecular mechanisms on the phase transition-dependent electrical impedance responses of the device in air

Naotoshi Nakashima, Yoshihisa Yamaguchi, Hideo Eda, Masahi Kunitake, Osamu Manabe

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

This paper describes the design and fabrication of a lipid film-modified electrical device and the relation between the chemical structure of the lipids and the impedance responses of the device in air. Eight different synthetic poly(ion-complexed) lipids including quaternary ammonium lipids, glutamic acid (Glu)-based lipids with a short or a long methylene spacer chain, and diethanolamine-based quaternary ammonium lipids with with a long or a short spacer chain were synthesized. Transparent multibilayer films with crystalline-to-liquid crystalline phase transition were formed, and impedance responses for interdigitated array electrodes coated with cast films of these lipids were examined. Complex plane plot analyses together with quartz crystal microbalance and FTIR experiments have revealed molecular mechanisms for the unique impedance responses which could be classified as the following three types. Type I is the phase transition-dependent impedance responses, where the impedance changes dramatically near the phase transition temperatures of the lipid bilayer films on the electrodes. The change is derived from the increase in the mobility of the ion-conducting carrier (protons) coupled with the phase transition. The lipid devices coated with cast films of quaternary ammonium lipids with no spacer or a short spacer belong to this type. Type II is a device coated with a cast film of a diethanolamine-based quaternary ammonium lipid with a long spacer. Tc-dependent impedance response similar to that in type I is observed, but the molecular mechanism of the response is different. Type III exhibits a phase transition-independent impedance response. Electrical devices using Glu-based primary ammonium lipids and a Glu-based quaternary ammonium lipid with a long spacer as electrode modifiers give this type of response. Conformational mobility of the hydrophilic head group moieties of these lipid bilayers is maintained rigid through hydrogen bonding even at temperatures higher than the phase transition which results in this response.

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalJournal of Physical Chemistry B
Volume101
Issue number2
Publication statusPublished - Jan 9 1997
Externally publishedYes

Fingerprint

Lipid bilayers
Acoustic impedance
electrical impedance
Lipids
lipids
Phase transitions
air
Air
Ammonium Compounds
diethanolamine
spacers
impedance
glutamic acid
Glutamic Acid
casts
Electrodes
Acids
electrodes
Ions
Crystalline materials

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Engineering(all)

Cite this

Design of a lipid bilayer electrical device. Strong chemical structure dependence and molecular mechanisms on the phase transition-dependent electrical impedance responses of the device in air. / Nakashima, Naotoshi; Yamaguchi, Yoshihisa; Eda, Hideo; Kunitake, Masahi; Manabe, Osamu.

In: Journal of Physical Chemistry B, Vol. 101, No. 2, 09.01.1997, p. 215-220.

Research output: Contribution to journalArticle

@article{9c0ee1fc56714d30bae1999338e6ab9b,
title = "Design of a lipid bilayer electrical device. Strong chemical structure dependence and molecular mechanisms on the phase transition-dependent electrical impedance responses of the device in air",
abstract = "This paper describes the design and fabrication of a lipid film-modified electrical device and the relation between the chemical structure of the lipids and the impedance responses of the device in air. Eight different synthetic poly(ion-complexed) lipids including quaternary ammonium lipids, glutamic acid (Glu)-based lipids with a short or a long methylene spacer chain, and diethanolamine-based quaternary ammonium lipids with with a long or a short spacer chain were synthesized. Transparent multibilayer films with crystalline-to-liquid crystalline phase transition were formed, and impedance responses for interdigitated array electrodes coated with cast films of these lipids were examined. Complex plane plot analyses together with quartz crystal microbalance and FTIR experiments have revealed molecular mechanisms for the unique impedance responses which could be classified as the following three types. Type I is the phase transition-dependent impedance responses, where the impedance changes dramatically near the phase transition temperatures of the lipid bilayer films on the electrodes. The change is derived from the increase in the mobility of the ion-conducting carrier (protons) coupled with the phase transition. The lipid devices coated with cast films of quaternary ammonium lipids with no spacer or a short spacer belong to this type. Type II is a device coated with a cast film of a diethanolamine-based quaternary ammonium lipid with a long spacer. Tc-dependent impedance response similar to that in type I is observed, but the molecular mechanism of the response is different. Type III exhibits a phase transition-independent impedance response. Electrical devices using Glu-based primary ammonium lipids and a Glu-based quaternary ammonium lipid with a long spacer as electrode modifiers give this type of response. Conformational mobility of the hydrophilic head group moieties of these lipid bilayers is maintained rigid through hydrogen bonding even at temperatures higher than the phase transition which results in this response.",
author = "Naotoshi Nakashima and Yoshihisa Yamaguchi and Hideo Eda and Masahi Kunitake and Osamu Manabe",
year = "1997",
month = "1",
day = "9",
language = "English",
volume = "101",
pages = "215--220",
journal = "Journal of Physical Chemistry B Materials",
issn = "1520-6106",
publisher = "American Chemical Society",
number = "2",

}

TY - JOUR

T1 - Design of a lipid bilayer electrical device. Strong chemical structure dependence and molecular mechanisms on the phase transition-dependent electrical impedance responses of the device in air

AU - Nakashima, Naotoshi

AU - Yamaguchi, Yoshihisa

AU - Eda, Hideo

AU - Kunitake, Masahi

AU - Manabe, Osamu

PY - 1997/1/9

Y1 - 1997/1/9

N2 - This paper describes the design and fabrication of a lipid film-modified electrical device and the relation between the chemical structure of the lipids and the impedance responses of the device in air. Eight different synthetic poly(ion-complexed) lipids including quaternary ammonium lipids, glutamic acid (Glu)-based lipids with a short or a long methylene spacer chain, and diethanolamine-based quaternary ammonium lipids with with a long or a short spacer chain were synthesized. Transparent multibilayer films with crystalline-to-liquid crystalline phase transition were formed, and impedance responses for interdigitated array electrodes coated with cast films of these lipids were examined. Complex plane plot analyses together with quartz crystal microbalance and FTIR experiments have revealed molecular mechanisms for the unique impedance responses which could be classified as the following three types. Type I is the phase transition-dependent impedance responses, where the impedance changes dramatically near the phase transition temperatures of the lipid bilayer films on the electrodes. The change is derived from the increase in the mobility of the ion-conducting carrier (protons) coupled with the phase transition. The lipid devices coated with cast films of quaternary ammonium lipids with no spacer or a short spacer belong to this type. Type II is a device coated with a cast film of a diethanolamine-based quaternary ammonium lipid with a long spacer. Tc-dependent impedance response similar to that in type I is observed, but the molecular mechanism of the response is different. Type III exhibits a phase transition-independent impedance response. Electrical devices using Glu-based primary ammonium lipids and a Glu-based quaternary ammonium lipid with a long spacer as electrode modifiers give this type of response. Conformational mobility of the hydrophilic head group moieties of these lipid bilayers is maintained rigid through hydrogen bonding even at temperatures higher than the phase transition which results in this response.

AB - This paper describes the design and fabrication of a lipid film-modified electrical device and the relation between the chemical structure of the lipids and the impedance responses of the device in air. Eight different synthetic poly(ion-complexed) lipids including quaternary ammonium lipids, glutamic acid (Glu)-based lipids with a short or a long methylene spacer chain, and diethanolamine-based quaternary ammonium lipids with with a long or a short spacer chain were synthesized. Transparent multibilayer films with crystalline-to-liquid crystalline phase transition were formed, and impedance responses for interdigitated array electrodes coated with cast films of these lipids were examined. Complex plane plot analyses together with quartz crystal microbalance and FTIR experiments have revealed molecular mechanisms for the unique impedance responses which could be classified as the following three types. Type I is the phase transition-dependent impedance responses, where the impedance changes dramatically near the phase transition temperatures of the lipid bilayer films on the electrodes. The change is derived from the increase in the mobility of the ion-conducting carrier (protons) coupled with the phase transition. The lipid devices coated with cast films of quaternary ammonium lipids with no spacer or a short spacer belong to this type. Type II is a device coated with a cast film of a diethanolamine-based quaternary ammonium lipid with a long spacer. Tc-dependent impedance response similar to that in type I is observed, but the molecular mechanism of the response is different. Type III exhibits a phase transition-independent impedance response. Electrical devices using Glu-based primary ammonium lipids and a Glu-based quaternary ammonium lipid with a long spacer as electrode modifiers give this type of response. Conformational mobility of the hydrophilic head group moieties of these lipid bilayers is maintained rigid through hydrogen bonding even at temperatures higher than the phase transition which results in this response.

UR - http://www.scopus.com/inward/record.url?scp=0031560543&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031560543&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0031560543

VL - 101

SP - 215

EP - 220

JO - Journal of Physical Chemistry B Materials

JF - Journal of Physical Chemistry B Materials

SN - 1520-6106

IS - 2

ER -