Design of a novel artificial nucleobase for the selective formation of a triple-complex with a cytosine-guanine base pair

Shigeki Sasaki, Shouji Nakashima, Fumi Nagatsugi, Yoshitsugu Tanaka, Masao Hisatome, Minoru Maeda

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A new artificial nucleobase (1) was designed for the selective formation of a triple-complex with a cytosine-guanine base pair at the major groove site. It has been proved based on the 1D- and 2D 1H-NMR spectra that the protected 2′-oxy-1 (7) forms a triplex complex with the GC pair selectively.

Original languageEnglish
Pages (from-to)9521-9524
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number52
DOIs
Publication statusPublished - Dec 25 1995

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Cytosine
Guanine
Base Pairing
Nuclear magnetic resonance
Proton Magnetic Resonance Spectroscopy

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Design of a novel artificial nucleobase for the selective formation of a triple-complex with a cytosine-guanine base pair. / Sasaki, Shigeki; Nakashima, Shouji; Nagatsugi, Fumi; Tanaka, Yoshitsugu; Hisatome, Masao; Maeda, Minoru.

In: Tetrahedron Letters, Vol. 36, No. 52, 25.12.1995, p. 9521-9524.

Research output: Contribution to journalArticle

Sasaki, Shigeki ; Nakashima, Shouji ; Nagatsugi, Fumi ; Tanaka, Yoshitsugu ; Hisatome, Masao ; Maeda, Minoru. / Design of a novel artificial nucleobase for the selective formation of a triple-complex with a cytosine-guanine base pair. In: Tetrahedron Letters. 1995 ; Vol. 36, No. 52. pp. 9521-9524.
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