Design of artificial metalloenzymes using non-covalent insertion of a metal complex into a protein scaffold

Takafumi Ueno, Tomomi Koshiyama, Satoshi Abe, Norihiko Yokoi, Masataka Ohashi, Hiroshi Nakajima, Yoshihito Watanabe

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)

Abstract

Construction of artificial metalloenzymes is one of the most attractive targets in the field of inorganic and catalytic chemistry, since they show remarkable chemoselectivity and reactivity in aqueous media. For the purpose, covalent modification of protein and cofactors have usually been utilized to attach a metal complex(es) to a protein scaffold. This article focuses on non-covalent insertion of metal complexes into protein environments. The discussion includes the screening of stable metal complex/protein composites, crystal structures, molecular design for regulating enantioselectivity of the target catalytic reactions. Our recent results show that the non-covalent conjugation will provide us a new way in semi-synthesis of artificial metalloenzymes.

Original languageEnglish
Pages (from-to)142-147
Number of pages6
JournalJournal of Organometallic Chemistry
Volume692
Issue number1-3
DOIs
Publication statusPublished - Jan 1 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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