TY - JOUR
T1 - Design of artificial metalloenzymes using non-covalent insertion of a metal complex into a protein scaffold
AU - Ueno, Takafumi
AU - Koshiyama, Tomomi
AU - Abe, Satoshi
AU - Yokoi, Norihiko
AU - Ohashi, Masataka
AU - Nakajima, Hiroshi
AU - Watanabe, Yoshihito
N1 - Funding Information:
This work was supported by 21st Century COE program of Nagoya University for T.K., S.A., and N.Y., and Grant-in-Aid for Scientific Research on Priority Areas (No. 16033226, “Reaction Control of Dynamic Complexes” and No. 16074208, “Chemistry of Coordination Space” for H.N. and Y.W., respectively) from Ministry of Education, Culture, Sports, Science and Technology, Japan.
PY - 2007/1/1
Y1 - 2007/1/1
N2 - Construction of artificial metalloenzymes is one of the most attractive targets in the field of inorganic and catalytic chemistry, since they show remarkable chemoselectivity and reactivity in aqueous media. For the purpose, covalent modification of protein and cofactors have usually been utilized to attach a metal complex(es) to a protein scaffold. This article focuses on non-covalent insertion of metal complexes into protein environments. The discussion includes the screening of stable metal complex/protein composites, crystal structures, molecular design for regulating enantioselectivity of the target catalytic reactions. Our recent results show that the non-covalent conjugation will provide us a new way in semi-synthesis of artificial metalloenzymes.
AB - Construction of artificial metalloenzymes is one of the most attractive targets in the field of inorganic and catalytic chemistry, since they show remarkable chemoselectivity and reactivity in aqueous media. For the purpose, covalent modification of protein and cofactors have usually been utilized to attach a metal complex(es) to a protein scaffold. This article focuses on non-covalent insertion of metal complexes into protein environments. The discussion includes the screening of stable metal complex/protein composites, crystal structures, molecular design for regulating enantioselectivity of the target catalytic reactions. Our recent results show that the non-covalent conjugation will provide us a new way in semi-synthesis of artificial metalloenzymes.
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U2 - 10.1016/j.jorganchem.2006.08.043
DO - 10.1016/j.jorganchem.2006.08.043
M3 - Article
AN - SCOPUS:33845610191
SN - 0022-328X
VL - 692
SP - 142
EP - 147
JO - Journal of Organometallic Chemistry
JF - Journal of Organometallic Chemistry
IS - 1-3
ER -