Design of highly efficient and selective transfer reaction of nitrosyl group to dC and d M C resulting in specific deamination

Md Monsur Ali, Fumi Nagatsugi, Shizuka Nakayama, Md Rowshon Alam, Takeshi Kawasaki, Shigeki Sasaki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Nitric oxide (NO) is an important endogenous regulatory molecule, and S-nitrosothiols are believed to play a significant role in NO storage, transport, and delivery. Based on the ability to generate NO in vivo, S-nitrosothiols can be used as therapeutic drugs. In this study, we have developed an innovative method for sequence- and base-specific delivery of NO to a specific site of DNA followed by specific deamination.

Original languageEnglish
Pages (from-to)721-724
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume24
Issue number5-7
DOIs
Publication statusPublished - Oct 20 2005
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Genetics

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