Design of novel biointerfaces (II). Fabrication of self-organized porous polymer film with highly uniform pores

Masaru Tanaka, Masafumi Takebayashi, Masashi Miyama, Jin Nishida, Masatsugu Shimomura

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Application of porous polymer materials to novel bio-interfaces for tissue engineering scaffold and artificial organs including blood filters, dialyzer, and oxygenator membranes have been in progress. The present study describes the fabrication and characterization of self-organized highly regular porous polymer films with uniform pore sizes are prepared by simple casting technique. Various fabrication parameters affecting the pore size such as polymer concentration, boiling point of solvent, cast volume and substrate are studied. The pore size can be controlled in the range from 1 to 50 μm by changing the evaporation rate of the polymer solutions. The porous film with uniform pore size is used for tissue engineering scaffold and cell separation membrane. To simulate the leukocyte eliminating from human blood, the porous film was attached to a module. The films with 5-9 μm pores provided the complete selectivity of separation for the leukocyte from the whole blood. The leukocyte elimination ratio depends on pore structures (size and depth) as well as recovery of platelet and erythrocyte.

Original languageEnglish
Pages (from-to)439-446
Number of pages8
JournalBio-Medical Materials and Engineering
Volume14
Issue number4
Publication statusPublished - 2004
Externally publishedYes

Fingerprint

Polymer films
Pore size
Polymers
Tissue Scaffolds
Fabrication
Leukocytes
Blood
Tissue Engineering
Scaffolds (biology)
Tissue engineering
Oxygenators
Membrane Oxygenators
Artificial Organs
Artificial organs
Artificial Kidneys
Membranes
Cell Separation
Boiling point
Polymer solutions
Pore structure

All Science Journal Classification (ASJC) codes

  • Biophysics

Cite this

Design of novel biointerfaces (II). Fabrication of self-organized porous polymer film with highly uniform pores. / Tanaka, Masaru; Takebayashi, Masafumi; Miyama, Masashi; Nishida, Jin; Shimomura, Masatsugu.

In: Bio-Medical Materials and Engineering, Vol. 14, No. 4, 2004, p. 439-446.

Research output: Contribution to journalArticle

Tanaka, Masaru ; Takebayashi, Masafumi ; Miyama, Masashi ; Nishida, Jin ; Shimomura, Masatsugu. / Design of novel biointerfaces (II). Fabrication of self-organized porous polymer film with highly uniform pores. In: Bio-Medical Materials and Engineering. 2004 ; Vol. 14, No. 4. pp. 439-446.
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