Design of Synthetic Polymer Nanoparticles Specifically Capturing Indole, a Small Toxic Molecule

Anna Okishima, Hiroyuki Koide, Yu Hoshino, Hiromichi Egami, Yoshitaka Hamashima, Naoto Oku, Tomohiro Asai

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Synthetic polymers are of interest as stable and cost-effective biomolecule-affinity reagents, since these polymers interact with target biomolecules both in vitro and in the bloodstream. However, little has been reported about orally administered polymers capable of capturing a target molecule and inhibiting its intestinal absorption. Here, we describe the design of synthetic polymer nanoparticles (NPs) specifically capturing indole, a major factor exacerbating chronic kidney disease, in the intestine. N-isopropylacrylamide-based NPs were prepared with various hydrophobic monomers. The amounts of indole captured by NPs depended on the structures and feed ratios of the hydrophobic monomers and the polymer density but not on the particle size. The combination of hydrophobic and quadrupole interaction was effective to enhance the affinity and specificity of NPs for indole. The optimized NPs specifically inhibited intestinal absorption of orally administered indole in mice. These results showed the potential of synthetic polymer NPs for inhibiting the intestinal absorption of a target molecule.

Original languageEnglish
Pages (from-to)1644-1654
Number of pages11
JournalBiomacromolecules
Volume20
Issue number4
DOIs
Publication statusPublished - Apr 8 2019

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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