Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide

Yu Hoshino, Takeo Urakami, Takashi Kodama, Hiroyuki Koide, Naoto Oku, Yoshio Okahata, Kenneth J. Shea

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Designed polymer nanoparticles (NPs) capable of binding and neutralizing a biomacromolecular toxin are prepared. A library of copolymer NPs is synthesized from combinations of functional monomers. The binding capacity and affinity of the NPs are individually analyzed. NPs with optimized composition are capable of neutralizing the toxin even in a complex biological milieu. It is anticipated that this strategy will be a starting point for the design of synthetic alternatives to antibodies.

Original languageEnglish
Pages (from-to)1562-1568
Number of pages7
JournalSmall
Volume5
Issue number13
DOIs
Publication statusPublished - Jul 3 2009
Externally publishedYes

Fingerprint

Poisons
Nanoparticles
Peptides
Polymers
Antibodies
Libraries
Copolymers
Monomers
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

Cite this

Hoshino, Y., Urakami, T., Kodama, T., Koide, H., Oku, N., Okahata, Y., & Shea, K. J. (2009). Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide. Small, 5(13), 1562-1568. https://doi.org/10.1002/smll.200900186

Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide. / Hoshino, Yu; Urakami, Takeo; Kodama, Takashi; Koide, Hiroyuki; Oku, Naoto; Okahata, Yoshio; Shea, Kenneth J.

In: Small, Vol. 5, No. 13, 03.07.2009, p. 1562-1568.

Research output: Contribution to journalArticle

Hoshino, Y, Urakami, T, Kodama, T, Koide, H, Oku, N, Okahata, Y & Shea, KJ 2009, 'Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide', Small, vol. 5, no. 13, pp. 1562-1568. https://doi.org/10.1002/smll.200900186
Hoshino, Yu ; Urakami, Takeo ; Kodama, Takashi ; Koide, Hiroyuki ; Oku, Naoto ; Okahata, Yoshio ; Shea, Kenneth J. / Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide. In: Small. 2009 ; Vol. 5, No. 13. pp. 1562-1568.
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