Design, synthesis and cytotoxic evaluation of o-carboxamido stilbene analogues

Mohamad Nurul Azmi, Mohd Fadzli Md Din, Chin Hui Kee, Munirah Suhaimi, Ang Kheng Ping, Kartini Ahmad, Mohd Azlan Nafiah, Noel F. Thomas, Khalit Mohamad, Leong Kok Hoong, Khalijah Awang

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Resveratrol, a natural stilbene found in grapes and wines exhibits a wide range of pharmacological properties. Resveratrol is also known as a good chemopreventive agent for inhibiting carcinogenesis processes that target kinases, cyclooxygenases, ribonucleotide reductase and DNA polymerases. A total of 19 analogues with an amide moiety were synthesized and the cytotoxic effects of the analogues on a series of human cancer cell lines are reported. Three compounds 6d, 6i and 6n showed potent cytotoxicity against prostate cancer DU-145 (IC50 = 16.68 μM), colon cancer HT-29 (IC50 = 7.51 μ M) and breast cancer MCF-7 (IC50 = 21.24 μM), respectively, which are comparable with vinblastine. The resveratrol analogues were synthesized using the Heck method.

Original languageEnglish
Pages (from-to)23369-23389
Number of pages21
JournalInternational journal of molecular sciences
Issue number12
Publication statusPublished - Nov 27 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


Dive into the research topics of 'Design, synthesis and cytotoxic evaluation of o-carboxamido stilbene analogues'. Together they form a unique fingerprint.

Cite this