Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors

Hideki Moriyama, Takahiro Tsukida, Yoshimasa Inoue, Hirosato Kondo, Kohichiro Yoshino, Shin Ichiro Nishimura

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In order to verify whether azasugar would be a useful scaffold for inhibitory activity against metalloproteinases, we synthesized some azasugar-based compounds. As a result, it is clarified that azasugar moiety could function as successful inhibitor of matrix metalloproteinase-1, -3 and -9 and TACE.

Original languageEnglish
Pages (from-to)2741-2744
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number16
DOIs
Publication statusPublished - Aug 18 2003

Fingerprint

Matrix Metalloproteinase 3
Matrix Metalloproteinase 1
Matrix Metalloproteinase Inhibitors
Metalloproteases
Matrix Metalloproteinases
Scaffolds

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors. / Moriyama, Hideki; Tsukida, Takahiro; Inoue, Yoshimasa; Kondo, Hirosato; Yoshino, Kohichiro; Nishimura, Shin Ichiro.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 16, 18.08.2003, p. 2741-2744.

Research output: Contribution to journalArticle

Moriyama, Hideki ; Tsukida, Takahiro ; Inoue, Yoshimasa ; Kondo, Hirosato ; Yoshino, Kohichiro ; Nishimura, Shin Ichiro. / Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors. In: Bioorganic and Medicinal Chemistry Letters. 2003 ; Vol. 13, No. 16. pp. 2741-2744.
@article{2e4eadbaf7524194967f5797e64b36ec,
title = "Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors",
abstract = "In order to verify whether azasugar would be a useful scaffold for inhibitory activity against metalloproteinases, we synthesized some azasugar-based compounds. As a result, it is clarified that azasugar moiety could function as successful inhibitor of matrix metalloproteinase-1, -3 and -9 and TACE.",
author = "Hideki Moriyama and Takahiro Tsukida and Yoshimasa Inoue and Hirosato Kondo and Kohichiro Yoshino and Nishimura, {Shin Ichiro}",
year = "2003",
month = "8",
day = "18",
doi = "10.1016/S0960-894X(03)00531-6",
language = "English",
volume = "13",
pages = "2741--2744",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "16",

}

TY - JOUR

T1 - Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors

AU - Moriyama, Hideki

AU - Tsukida, Takahiro

AU - Inoue, Yoshimasa

AU - Kondo, Hirosato

AU - Yoshino, Kohichiro

AU - Nishimura, Shin Ichiro

PY - 2003/8/18

Y1 - 2003/8/18

N2 - In order to verify whether azasugar would be a useful scaffold for inhibitory activity against metalloproteinases, we synthesized some azasugar-based compounds. As a result, it is clarified that azasugar moiety could function as successful inhibitor of matrix metalloproteinase-1, -3 and -9 and TACE.

AB - In order to verify whether azasugar would be a useful scaffold for inhibitory activity against metalloproteinases, we synthesized some azasugar-based compounds. As a result, it is clarified that azasugar moiety could function as successful inhibitor of matrix metalloproteinase-1, -3 and -9 and TACE.

UR - http://www.scopus.com/inward/record.url?scp=0037811296&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037811296&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(03)00531-6

DO - 10.1016/S0960-894X(03)00531-6

M3 - Article

C2 - 12873505

AN - SCOPUS:0037811296

VL - 13

SP - 2741

EP - 2744

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 16

ER -