Detailed analysis of Japanese population substructure with a focus on the Southwest Islands of Japan

Takeshi Nishiyama, Hirohisa Kishino, Sadao Suzuki, Ryosuke Ando, Hideshi Niimura, Hirokazu Uemura, Mikako Horita, Ohnaka Keizo, Nagato Kuriyama, Haruo Mikami, Naoyuki Takashima, Keitaro Mastuo, Yin Guang, Kenji Wakai, Nobuyuki Hamajima, Hideo Tanaka

Research output: Contribution to journalArticle

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Abstract

Uncovering population structure is important for properly conducting association studies and for examining the demographic history of a population. Here, we examined the Japanese population substructure using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC), which covers all but the northern region of Japan. Using 222 autosomal loci from 4502 subjects, we investigated population substructure by estimating F ST among populations, testing population differentiation, and performing principal component analysis (PCA) and correspondence analysis (CA). All analyses revealed a low but significant differentiation between the Amami Islanders and the mainland Japanese population. Furthermore, we examined the genetic differentiation between the mainland population, Amami Islanders and Okinawa Islanders using six loci included in both the Pan-Asian SNP (PASNP) consortium data and the J-MICC data. This analysis revealed that the Amami and Okinawa Islanders were differentiated from the mainland population. In conclusion, we revealed a low but significant level of genetic differentiation between the mainland population and populations in or to the south of the Amami Islands, although genetic variation between both populations might be clinal. Therefore, the possibility of population stratification must be considered when enrolling the islander population of this area, such as in the J-MICC study.

Original languageEnglish
Article numbere35000
JournalPloS one
Volume7
Issue number4
DOIs
Publication statusPublished - Apr 3 2012

Fingerprint

Islands
Principal component analysis
Japan
Testing
Population
Ryukyu Archipelago
genetic variation
loci
cohort studies
Principal Component Analysis
Single Nucleotide Polymorphism
population structure
principal component analysis
demographic statistics
Cohort Studies
History
Demography

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Nishiyama, T., Kishino, H., Suzuki, S., Ando, R., Niimura, H., Uemura, H., ... Tanaka, H. (2012). Detailed analysis of Japanese population substructure with a focus on the Southwest Islands of Japan. PloS one, 7(4), [e35000]. https://doi.org/10.1371/journal.pone.0035000

Detailed analysis of Japanese population substructure with a focus on the Southwest Islands of Japan. / Nishiyama, Takeshi; Kishino, Hirohisa; Suzuki, Sadao; Ando, Ryosuke; Niimura, Hideshi; Uemura, Hirokazu; Horita, Mikako; Keizo, Ohnaka; Kuriyama, Nagato; Mikami, Haruo; Takashima, Naoyuki; Mastuo, Keitaro; Guang, Yin; Wakai, Kenji; Hamajima, Nobuyuki; Tanaka, Hideo.

In: PloS one, Vol. 7, No. 4, e35000, 03.04.2012.

Research output: Contribution to journalArticle

Nishiyama, T, Kishino, H, Suzuki, S, Ando, R, Niimura, H, Uemura, H, Horita, M, Keizo, O, Kuriyama, N, Mikami, H, Takashima, N, Mastuo, K, Guang, Y, Wakai, K, Hamajima, N & Tanaka, H 2012, 'Detailed analysis of Japanese population substructure with a focus on the Southwest Islands of Japan', PloS one, vol. 7, no. 4, e35000. https://doi.org/10.1371/journal.pone.0035000
Nishiyama, Takeshi ; Kishino, Hirohisa ; Suzuki, Sadao ; Ando, Ryosuke ; Niimura, Hideshi ; Uemura, Hirokazu ; Horita, Mikako ; Keizo, Ohnaka ; Kuriyama, Nagato ; Mikami, Haruo ; Takashima, Naoyuki ; Mastuo, Keitaro ; Guang, Yin ; Wakai, Kenji ; Hamajima, Nobuyuki ; Tanaka, Hideo. / Detailed analysis of Japanese population substructure with a focus on the Southwest Islands of Japan. In: PloS one. 2012 ; Vol. 7, No. 4.
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