TY - JOUR
T1 - Detection and analysis of photothermal signal generated in capillary channel flow
AU - Hirashima, Satoshi
AU - Katae, Hitoshi
AU - Harata, Akira
PY - 2009/7
Y1 - 2009/7
N2 - A photothermal signal from a liquid sample in a capillary channel flow is detected and analyzed to optimize experimental conditions of microfluidic devices used for separation. A theoretical model for photoinduced temperature increase and photothermal signal intensity generated by intensity-modulated cw excitation beams at a crossed-beam configuration is proposed. Four experimental parameters (probe beam offset, excitation beam chopping frequency, linear flow velocity, and excitation beam size) and physical properties of solvent mainly dominate the signal. The model well explains the photothermal signal obtained experimentally under low velocity and high chopping frequency conditions. The obtained results make it possible to optimize the experimental conditions for the highly sensitive detection of chemicals under flow conditions.
AB - A photothermal signal from a liquid sample in a capillary channel flow is detected and analyzed to optimize experimental conditions of microfluidic devices used for separation. A theoretical model for photoinduced temperature increase and photothermal signal intensity generated by intensity-modulated cw excitation beams at a crossed-beam configuration is proposed. Four experimental parameters (probe beam offset, excitation beam chopping frequency, linear flow velocity, and excitation beam size) and physical properties of solvent mainly dominate the signal. The model well explains the photothermal signal obtained experimentally under low velocity and high chopping frequency conditions. The obtained results make it possible to optimize the experimental conditions for the highly sensitive detection of chemicals under flow conditions.
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U2 - 10.1143/JJAP.48.07GE04
DO - 10.1143/JJAP.48.07GE04
M3 - Article
AN - SCOPUS:72049106918
SN - 0021-4922
VL - 48
JO - Japanese Journal of Applied Physics
JF - Japanese Journal of Applied Physics
IS - 7 PART 2
M1 - 07GE04
ER -