Detection and inhibition of redox reaction and lipid derived radicals

Research output: Contribution to journalArticle

Abstract

In development of many oxidative disease, change of redox reaction and generation of free radicals have been reported to be involved. Here, for detection of redox status and free radical reaction (especially, lipid-derived radicals), we focus on nitroxide compounds having stable unpaired electrons in the molecule. Since this molecule can react with redox compounds or bind with carbon-centered radicals, we can use a detection probe for these molecules in experimental animal models. In this paper, we show that lipid-derived radicals are generated during induction of chemical carcinogenesis and light-induced retinal damages in animal models using this probes, and this information will provide the timing of inhibitor injection to the animals. In other words, we will explain the study of theranostics through detection and inhibition of lipid-derived radicals.

Original languageEnglish
Pages (from-to)197-203
Number of pages7
JournalDrug Delivery System
Volume33
Issue number3
DOIs
Publication statusPublished - Jan 1 2018

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Oxidation-Reduction
Lipids
Free Radicals
Animal Models
Carcinogenesis
Carbon
Electrons
Light
Injections
Theranostic Nanomedicine

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Detection and inhibition of redox reaction and lipid derived radicals. / Yamada, Ken-Ichi.

In: Drug Delivery System, Vol. 33, No. 3, 01.01.2018, p. 197-203.

Research output: Contribution to journalArticle

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