Detection, characterization, and clinical application of mesenchymal stem cells in periodontal ligament tissue

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) are a kind of somatic stem cells that exert a potential to differentiate into multiple cell types and undergo robust clonal self-renewal; therefore, they are considered as a highly promising stem cell population for tissue engineering. MSCs are identified in various adult organs including dental tissues. Periodontal ligament (PDL) is a highly specialized connective tissue that surrounds the tooth root. PDL also contains MSC population, and many researchers have isolated them and performed their detailed characterization. Here, we review the current understanding of the features and functions of MSC population in PDL tissues and discuss their possibility for the application of PDL regeneration.

Original languageEnglish
Article number5450768
JournalStem Cells International
Volume2018
DOIs
Publication statusPublished - Jan 1 2018

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Periodontal Ligament
Mesenchymal Stromal Cells
Population
Tooth Root
Adult Stem Cells
Tissue Engineering
Connective Tissue
Regeneration
Tooth
Stem Cells
Research Personnel

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

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title = "Detection, characterization, and clinical application of mesenchymal stem cells in periodontal ligament tissue",
abstract = "Mesenchymal stem cells (MSCs) are a kind of somatic stem cells that exert a potential to differentiate into multiple cell types and undergo robust clonal self-renewal; therefore, they are considered as a highly promising stem cell population for tissue engineering. MSCs are identified in various adult organs including dental tissues. Periodontal ligament (PDL) is a highly specialized connective tissue that surrounds the tooth root. PDL also contains MSC population, and many researchers have isolated them and performed their detailed characterization. Here, we review the current understanding of the features and functions of MSC population in PDL tissues and discuss their possibility for the application of PDL regeneration.",
author = "Atsushi Tomokiyo and Shinichiro Yoshida and Sayuri Hamano and Daigaku Hasegawa and Hideki Sugii and Hidefumi Maeda",
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AU - Tomokiyo, Atsushi

AU - Yoshida, Shinichiro

AU - Hamano, Sayuri

AU - Hasegawa, Daigaku

AU - Sugii, Hideki

AU - Maeda, Hidefumi

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Mesenchymal stem cells (MSCs) are a kind of somatic stem cells that exert a potential to differentiate into multiple cell types and undergo robust clonal self-renewal; therefore, they are considered as a highly promising stem cell population for tissue engineering. MSCs are identified in various adult organs including dental tissues. Periodontal ligament (PDL) is a highly specialized connective tissue that surrounds the tooth root. PDL also contains MSC population, and many researchers have isolated them and performed their detailed characterization. Here, we review the current understanding of the features and functions of MSC population in PDL tissues and discuss their possibility for the application of PDL regeneration.

AB - Mesenchymal stem cells (MSCs) are a kind of somatic stem cells that exert a potential to differentiate into multiple cell types and undergo robust clonal self-renewal; therefore, they are considered as a highly promising stem cell population for tissue engineering. MSCs are identified in various adult organs including dental tissues. Periodontal ligament (PDL) is a highly specialized connective tissue that surrounds the tooth root. PDL also contains MSC population, and many researchers have isolated them and performed their detailed characterization. Here, we review the current understanding of the features and functions of MSC population in PDL tissues and discuss their possibility for the application of PDL regeneration.

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