Detection, characterization, and clinical application of mesenchymal stem cells in periodontal ligament tissue

Atsushi Tomokiyo; Shinichiro Yoshida; Sayuri Hamano; Daigaku Hasegawa; Hideki Sugii; Hidefumi Maeda

doi:10.1155/2018/5450768

Detection, characterization, and clinical application of mesenchymal stem cells in periodontal ligament tissue

Atsushi Tomokiyo, Shinichiro Yoshida, Sayuri Hamano, Daigaku Hasegawa, Hideki Sugii, Hidefumi Maeda

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) are a kind of somatic stem cells that exert a potential to differentiate into multiple cell types and undergo robust clonal self-renewal; therefore, they are considered as a highly promising stem cell population for tissue engineering. MSCs are identified in various adult organs including dental tissues. Periodontal ligament (PDL) is a highly specialized connective tissue that surrounds the tooth root. PDL also contains MSC population, and many researchers have isolated them and performed their detailed characterization. Here, we review the current understanding of the features and functions of MSC population in PDL tissues and discuss their possibility for the application of PDL regeneration.

Original language	English
Article number	5450768
Journal	Stem Cells International
Volume	2018
DOIs	https://doi.org/10.1155/2018/5450768
Publication status	Published - 2018

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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title = "Detection, characterization, and clinical application of mesenchymal stem cells in periodontal ligament tissue",

abstract = "Mesenchymal stem cells (MSCs) are a kind of somatic stem cells that exert a potential to differentiate into multiple cell types and undergo robust clonal self-renewal; therefore, they are considered as a highly promising stem cell population for tissue engineering. MSCs are identified in various adult organs including dental tissues. Periodontal ligament (PDL) is a highly specialized connective tissue that surrounds the tooth root. PDL also contains MSC population, and many researchers have isolated them and performed their detailed characterization. Here, we review the current understanding of the features and functions of MSC population in PDL tissues and discuss their possibility for the application of PDL regeneration.",

author = "Atsushi Tomokiyo and Shinichiro Yoshida and Sayuri Hamano and Daigaku Hasegawa and Hideki Sugii and Hidefumi Maeda",

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AU - Tomokiyo, Atsushi

AU - Yoshida, Shinichiro

AU - Hamano, Sayuri

AU - Hasegawa, Daigaku

AU - Sugii, Hideki

AU - Maeda, Hidefumi

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