Detection of Antibodies to Leptospiral Genus-Specific Antigen in Human and Animal Sera by Indirect Hemagglutination Test with a Partially Purified Genus-Specific Protein Antigen

Noritsugu Sakamoto, Ryo Yanagawa, Etsuro Ono, Hiroshi Kida, Mamoru Mori, Yoshiko Arimitsu, Kiyoto Akama, Jun Yasuda, Kimehiko Too

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4 Citations (Scopus)

Abstract

Antibodies against leptospiral genus-specific antigen were detected in the sera from clinically diagnosed human leptospirosis and suspected animal leptospirosis by indirect hemagglutination (IHA) test with a partially purified genus-specific protein antigen (GP-Ag). The reaction was positive in the infected humans and animals irrespective of the leptospiral serovars. No significant correlation was found between IHA titer against GP-Ag and microscopic agglutination (MA) titer. IHA titer did not always develop in parallel with MA titers. Sera obtained from healthy individuals were negative in both IHA and MA tests.

Original languageEnglish
Pages (from-to)548-556
Number of pages9
JournalZentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A
Volume259
Issue number4
DOIs
Publication statusPublished - 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology

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