Detection of calprotectin and apoptotic activity in the colon of marmosets with chronic diarrhea

Erika Nakashima, Yasushi Okano, Kimie Niimi, Eiki Takahashi

Research output: Contribution to journalComment/debatepeer-review

11 Citations (Scopus)

Abstract

The common marmoset (Callithrix jacchus is used as a non-human primate laboratory animal. Marmoset wasting syndrome (MWS is a disease endemic to captive colonies, and the pathogenesis is unclear. In the present study, marmosets with chronic bloody highviscosity diarrhea, which is a contributing factor to MWS, were evaluated, and inflammation in the colon was found. Calprotectin is a surrogate marker of intestinal inflammation and induces apoptosis. Marmosets with chronic diarrhea exhibited higher levels of fecal calprotectin. Histochemical analyses showed high expression of calprotectin in the extravascular neutrophils and apoptosis in the chronic colitis lesions. No internal microbiological diseases were identified. Although the cause of chronic colitis was not identified, the marmoset could be a useful model of inflammatory bowel disease.

Original languageEnglish
Pages (from-to)1633-1636
Number of pages4
JournalJournal of Veterinary Medical Science
Volume75
Issue number12
DOIs
Publication statusPublished - 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • veterinary(all)

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