Detection of combined hepatocellular and cholangiocarcinomas on enhanced CT: Comparison with histologic findings

Akihiro Nishie, Kengo Yoshimitsu, Yoshiki Asayama, Hiroyuki Irie, Hitoshi Aibe, Tsuyoshi Tajima, Kenji Shinozaki, Tomohiro Nakayama, Daisuke Kakihara, Mitsuo Shimada, Shin Ichi Aishima, Kisaku Yoshida, Hiroshi Honda

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Abstract

OBJECTIVE. The purpose of this study was to evaluate the performance of enhanced CT in making a diagnosis of combined hepatocellular and cholangiocarcinomas (HCC-CCs) by comparing CT findings with histologic findings. CONCLUSION. One third (nine of 27 cases) of the combined HCC-CCs were correctly diagnosed on enhanced CT by detailed analysis of the enhancing pattern around or within the mass. Various factors such as an atypical enhancing pattern, the size of each component, and the presence of a mass composed of intermediate tumor cells-that is, cells with intermediate characteristics between HCC and CC-were found to be the causes of misdiagnosis of combined HCC-CC on enhanced CT.

Original languageEnglish
Pages (from-to)1157-1162
Number of pages6
JournalAmerican Journal of Roentgenology
Volume184
Issue number4
DOIs
Publication statusPublished - Jan 1 2005

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Cholangiocarcinoma
Diagnostic Errors
Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Detection of combined hepatocellular and cholangiocarcinomas on enhanced CT : Comparison with histologic findings. / Nishie, Akihiro; Yoshimitsu, Kengo; Asayama, Yoshiki; Irie, Hiroyuki; Aibe, Hitoshi; Tajima, Tsuyoshi; Shinozaki, Kenji; Nakayama, Tomohiro; Kakihara, Daisuke; Shimada, Mitsuo; Aishima, Shin Ichi; Yoshida, Kisaku; Honda, Hiroshi.

In: American Journal of Roentgenology, Vol. 184, No. 4, 01.01.2005, p. 1157-1162.

Research output: Contribution to journalArticle

Nishie, A, Yoshimitsu, K, Asayama, Y, Irie, H, Aibe, H, Tajima, T, Shinozaki, K, Nakayama, T, Kakihara, D, Shimada, M, Aishima, SI, Yoshida, K & Honda, H 2005, 'Detection of combined hepatocellular and cholangiocarcinomas on enhanced CT: Comparison with histologic findings', American Journal of Roentgenology, vol. 184, no. 4, pp. 1157-1162. https://doi.org/10.2214/ajr.184.4.01841157
Nishie, Akihiro ; Yoshimitsu, Kengo ; Asayama, Yoshiki ; Irie, Hiroyuki ; Aibe, Hitoshi ; Tajima, Tsuyoshi ; Shinozaki, Kenji ; Nakayama, Tomohiro ; Kakihara, Daisuke ; Shimada, Mitsuo ; Aishima, Shin Ichi ; Yoshida, Kisaku ; Honda, Hiroshi. / Detection of combined hepatocellular and cholangiocarcinomas on enhanced CT : Comparison with histologic findings. In: American Journal of Roentgenology. 2005 ; Vol. 184, No. 4. pp. 1157-1162.
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AU - Yoshimitsu, Kengo

AU - Asayama, Yoshiki

AU - Irie, Hiroyuki

AU - Aibe, Hitoshi

AU - Tajima, Tsuyoshi

AU - Shinozaki, Kenji

AU - Nakayama, Tomohiro

AU - Kakihara, Daisuke

AU - Shimada, Mitsuo

AU - Aishima, Shin Ichi

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AU - Honda, Hiroshi

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AB - OBJECTIVE. The purpose of this study was to evaluate the performance of enhanced CT in making a diagnosis of combined hepatocellular and cholangiocarcinomas (HCC-CCs) by comparing CT findings with histologic findings. CONCLUSION. One third (nine of 27 cases) of the combined HCC-CCs were correctly diagnosed on enhanced CT by detailed analysis of the enhancing pattern around or within the mass. Various factors such as an atypical enhancing pattern, the size of each component, and the presence of a mass composed of intermediate tumor cells-that is, cells with intermediate characteristics between HCC and CC-were found to be the causes of misdiagnosis of combined HCC-CC on enhanced CT.

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