Detection of hepatocellular carcinoma (HCC) using super paramagnetic iron oxide (SPIO)-enhanced mri: Added value of diffusion-weighted imaging (DWI)

Akihiro Nishie, Tsuyoshi Tajima, Kousei Ishigami, Yasuhiro Ushijima, Daisuke Okamoto, Masakazu Hirakawa, Yunosuke Nishihara, Akinobu Taketomi, Masamitsu Hatakenaka, Hiroyuki Irie, Kengo Yoshimitsu, Hiroshi Honda

Research output: Contribution to journalArticle

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Abstract

Purpose: To evaluate whether diffusion-weighted imaging (DWI) improves the detection of hepatocellular carcinoma (HCC) on super paramagnetic iron oxide (SPIO)-enhanced MRI. Materials and Methods: This retrospective study group consisted of 30 patients with 50 HCC nodules who underwent MRI at 1.5 Tesla. Two combined MR sequence sets were compared for detecting HCC: SPIO-enhanced MRI (axial T2-weighted fast spin-echo (FSE) and T1-/T2*-weighted fast field echo (FFE) scanned before and after administration of ferucarbotran) and SPIO-enhanced MRI + DWI (SPIO-enhanced MRI with axial DWI scanned before and after administration of ferucarbotran). Three blinded readers independently reviewed for the presence of HCC on a segment-by-segment basis using a four-point confidence scale. The performance of the two combined MR sequence sets was evaluated using receiver operating characteristic (ROC) analysis. Results: The average area under the ROC curve (Az) of the three readers for the SPIO-enhanced MRI + DWI set (0.870 ± 0.046) was significantly higher that that for the SPIO-enhanced MRI set (0.820 ± 0.055) (P = .025). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for detection of HCC were 66.0%, 98.0%, 90.0%, and 91.4%, respectively, for the SPIO-enhanced MRI set, and 70.0%, 98.6%, 92.9%, and 92.4%, respectively, for the SPIO-enhanced MRI + DWI set. Conclusion: The SPIO-enhanced MRI + DWI set outperformed the SPIO-enhanced MRI set for depicting HCC.

Original languageEnglish
Pages (from-to)373-382
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Volume31
Issue number2
DOIs
Publication statusPublished - Feb 1 2010

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Hepatocellular Carcinoma
Diffusion Magnetic Resonance Imaging
ROC Curve
ferric oxide
Retrospective Studies
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Detection of hepatocellular carcinoma (HCC) using super paramagnetic iron oxide (SPIO)-enhanced mri : Added value of diffusion-weighted imaging (DWI). / Nishie, Akihiro; Tajima, Tsuyoshi; Ishigami, Kousei; Ushijima, Yasuhiro; Okamoto, Daisuke; Hirakawa, Masakazu; Nishihara, Yunosuke; Taketomi, Akinobu; Hatakenaka, Masamitsu; Irie, Hiroyuki; Yoshimitsu, Kengo; Honda, Hiroshi.

In: Journal of Magnetic Resonance Imaging, Vol. 31, No. 2, 01.02.2010, p. 373-382.

Research output: Contribution to journalArticle

Nishie, Akihiro ; Tajima, Tsuyoshi ; Ishigami, Kousei ; Ushijima, Yasuhiro ; Okamoto, Daisuke ; Hirakawa, Masakazu ; Nishihara, Yunosuke ; Taketomi, Akinobu ; Hatakenaka, Masamitsu ; Irie, Hiroyuki ; Yoshimitsu, Kengo ; Honda, Hiroshi. / Detection of hepatocellular carcinoma (HCC) using super paramagnetic iron oxide (SPIO)-enhanced mri : Added value of diffusion-weighted imaging (DWI). In: Journal of Magnetic Resonance Imaging. 2010 ; Vol. 31, No. 2. pp. 373-382.
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abstract = "Purpose: To evaluate whether diffusion-weighted imaging (DWI) improves the detection of hepatocellular carcinoma (HCC) on super paramagnetic iron oxide (SPIO)-enhanced MRI. Materials and Methods: This retrospective study group consisted of 30 patients with 50 HCC nodules who underwent MRI at 1.5 Tesla. Two combined MR sequence sets were compared for detecting HCC: SPIO-enhanced MRI (axial T2-weighted fast spin-echo (FSE) and T1-/T2*-weighted fast field echo (FFE) scanned before and after administration of ferucarbotran) and SPIO-enhanced MRI + DWI (SPIO-enhanced MRI with axial DWI scanned before and after administration of ferucarbotran). Three blinded readers independently reviewed for the presence of HCC on a segment-by-segment basis using a four-point confidence scale. The performance of the two combined MR sequence sets was evaluated using receiver operating characteristic (ROC) analysis. Results: The average area under the ROC curve (Az) of the three readers for the SPIO-enhanced MRI + DWI set (0.870 ± 0.046) was significantly higher that that for the SPIO-enhanced MRI set (0.820 ± 0.055) (P = .025). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for detection of HCC were 66.0{\%}, 98.0{\%}, 90.0{\%}, and 91.4{\%}, respectively, for the SPIO-enhanced MRI set, and 70.0{\%}, 98.6{\%}, 92.9{\%}, and 92.4{\%}, respectively, for the SPIO-enhanced MRI + DWI set. Conclusion: The SPIO-enhanced MRI + DWI set outperformed the SPIO-enhanced MRI set for depicting HCC.",
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T1 - Detection of hepatocellular carcinoma (HCC) using super paramagnetic iron oxide (SPIO)-enhanced mri

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AU - Nishie, Akihiro

AU - Tajima, Tsuyoshi

AU - Ishigami, Kousei

AU - Ushijima, Yasuhiro

AU - Okamoto, Daisuke

AU - Hirakawa, Masakazu

AU - Nishihara, Yunosuke

AU - Taketomi, Akinobu

AU - Hatakenaka, Masamitsu

AU - Irie, Hiroyuki

AU - Yoshimitsu, Kengo

AU - Honda, Hiroshi

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N2 - Purpose: To evaluate whether diffusion-weighted imaging (DWI) improves the detection of hepatocellular carcinoma (HCC) on super paramagnetic iron oxide (SPIO)-enhanced MRI. Materials and Methods: This retrospective study group consisted of 30 patients with 50 HCC nodules who underwent MRI at 1.5 Tesla. Two combined MR sequence sets were compared for detecting HCC: SPIO-enhanced MRI (axial T2-weighted fast spin-echo (FSE) and T1-/T2*-weighted fast field echo (FFE) scanned before and after administration of ferucarbotran) and SPIO-enhanced MRI + DWI (SPIO-enhanced MRI with axial DWI scanned before and after administration of ferucarbotran). Three blinded readers independently reviewed for the presence of HCC on a segment-by-segment basis using a four-point confidence scale. The performance of the two combined MR sequence sets was evaluated using receiver operating characteristic (ROC) analysis. Results: The average area under the ROC curve (Az) of the three readers for the SPIO-enhanced MRI + DWI set (0.870 ± 0.046) was significantly higher that that for the SPIO-enhanced MRI set (0.820 ± 0.055) (P = .025). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for detection of HCC were 66.0%, 98.0%, 90.0%, and 91.4%, respectively, for the SPIO-enhanced MRI set, and 70.0%, 98.6%, 92.9%, and 92.4%, respectively, for the SPIO-enhanced MRI + DWI set. Conclusion: The SPIO-enhanced MRI + DWI set outperformed the SPIO-enhanced MRI set for depicting HCC.

AB - Purpose: To evaluate whether diffusion-weighted imaging (DWI) improves the detection of hepatocellular carcinoma (HCC) on super paramagnetic iron oxide (SPIO)-enhanced MRI. Materials and Methods: This retrospective study group consisted of 30 patients with 50 HCC nodules who underwent MRI at 1.5 Tesla. Two combined MR sequence sets were compared for detecting HCC: SPIO-enhanced MRI (axial T2-weighted fast spin-echo (FSE) and T1-/T2*-weighted fast field echo (FFE) scanned before and after administration of ferucarbotran) and SPIO-enhanced MRI + DWI (SPIO-enhanced MRI with axial DWI scanned before and after administration of ferucarbotran). Three blinded readers independently reviewed for the presence of HCC on a segment-by-segment basis using a four-point confidence scale. The performance of the two combined MR sequence sets was evaluated using receiver operating characteristic (ROC) analysis. Results: The average area under the ROC curve (Az) of the three readers for the SPIO-enhanced MRI + DWI set (0.870 ± 0.046) was significantly higher that that for the SPIO-enhanced MRI set (0.820 ± 0.055) (P = .025). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for detection of HCC were 66.0%, 98.0%, 90.0%, and 91.4%, respectively, for the SPIO-enhanced MRI set, and 70.0%, 98.6%, 92.9%, and 92.4%, respectively, for the SPIO-enhanced MRI + DWI set. Conclusion: The SPIO-enhanced MRI + DWI set outperformed the SPIO-enhanced MRI set for depicting HCC.

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