Detection of human herpes virus 6 (HHV 6) in the skin of a patient with primary HHV 6 infection and erythroderma

Y. Sumiyoshi, M. Kikuchi, Koichi Akashi

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Abstract

Human herpes virus 6 (HHV 6) has been implicated as the causative agent of exanthema subitum in young children. Recently, we reported two cases of a severe, infectious, mononucleosis-like syndrome resulting from a primary HHV 6 infection in immunocompetent adults. Both of these patients had the skin condition generally referred to as "erythroderma". A skin-biopsy specimen from one of them, a 43 year old man, was examined. Using immunohistochemical staining and in situ hybridisation, lymphocytes infected with HHV 6 were found in the skin. It is proposed that the erythroderma in immunocompetent adults infected with primary HHV 6 is provoked by infiltration of infected inflammatory cells or infected neoplastic lymphocytes into the dermis.

Original languageEnglish
Pages (from-to)762-763
Number of pages2
JournalJournal of Clinical Pathology
Volume47
Issue number8
DOIs
Publication statusPublished - Jan 1 1994

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Exfoliative Dermatitis
Virus Diseases
Viruses
Skin
Exanthema Subitum
Lymphocytes
Infectious Mononucleosis
Dermis
In Situ Hybridization
Staining and Labeling
Biopsy

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Detection of human herpes virus 6 (HHV 6) in the skin of a patient with primary HHV 6 infection and erythroderma. / Sumiyoshi, Y.; Kikuchi, M.; Akashi, Koichi.

In: Journal of Clinical Pathology, Vol. 47, No. 8, 01.01.1994, p. 762-763.

Research output: Contribution to journalArticle

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