Detection of non Watson-Crick base pairing based on colloidal stability change of DNA-linked nanoparticles

Emi Imaizumi, Tohru Takarada, Tang Zhonglan, Daisuke Miyamoto, Shunichi Uchiyama, Mizuo Maeda

Research output: Contribution to conferencePaper

Abstract

Colloidal nanoparticles carrying double-stranded DNAs on their surfaces undergo dispersion only when a terminal single-base mismatch exists at the interface between a DNA-shell and bulk. Based on the drastic change of colloidal stability, we developed a facile method to evaluate the thermal stability of a non Watson-Crick base pair between an oxidative-damaged guanine (8-oxoG) and each four natural nucleobase.

Original languageEnglish
Number of pages1
Publication statusPublished - Dec 1 2005
Externally publishedYes
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: Sep 20 2005Sep 22 2005

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period9/20/059/22/05

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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    Imaizumi, E., Takarada, T., Zhonglan, T., Miyamoto, D., Uchiyama, S., & Maeda, M. (2005). Detection of non Watson-Crick base pairing based on colloidal stability change of DNA-linked nanoparticles. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.