Detection of suppression of bitterness by sweet substance using a multichannel taste sensor

Sou Takagi, Kiyoshi Toko, Koichi Wada, Hiromi Yamada, Kenzo Toyoshima

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

A multichannel taste sensor whose transducer is composed of several kinds of lipid/polymer membranes with different characteristics can detect taste in a manner similar to human gustatory sensation. Taste information is transformed into a pattern composed of electric signals of membrane potentials of the receptor part. In the present study, it was shown that the suppression of the bitterness of quinine and a drug substance by sucrose can be quantified using a multichannel taste sensor. The present method can be expected to provide a new automated method to measure the strength of bitterness of drug substance in the place of sensory evaluation.

Original languageEnglish
Pages (from-to)552-555
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume87
Issue number5
DOIs
Publication statusPublished - Jan 1 1998

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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