We have investigated the functionality of saccharide-modified gold nanoparticles and apply for detection of toxic protein such as Shiga toxin and RCA120. Lactose, Gb2 and Gb3 derivatives were synthesized by thioglycosylation method. Gold nanoparticles have been prepared by Brust-Schiffrin method and modified the surface with saccharide derivatives by thiol exchange reaction. Although the lactose-modified gold nanoparticles dispersed stably in aqueous solution, it showed rapid and specific aggregation by the addition of RCA120.
|Number of pages||1|
|Publication status||Published - Dec 1 2005|
|Event||54th SPSJ Symposium on Macromolecules - Yamagata, Japan|
Duration: Sep 20 2005 → Sep 22 2005
|Other||54th SPSJ Symposium on Macromolecules|
|Period||9/20/05 → 9/22/05|
All Science Journal Classification (ASJC) codes