Determining important regulatory relations of amino acids from dynamic network analysis of plasma amino acids

Nahoko Shikata, Yukihiro Maki, Masahiko Nakatsui, Masato Mori, Yasushi Noguchi, Shintaro Yoshida, Michio Takahashi, Nobuo Kondo, Masahiro Okamoto

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The changes in the concentrations of plasma amino acids do not always follow the flow-based metabolic pathway network. We have previously shown that there is a control-based network structure among plasma amino acids besides the metabolic pathway map. Based on this network structure, in this study, we performed dynamic analysis using time-course data of the plasma samples of rats fed single essential amino acid deficient diet. Using S-system model (conceptual mathematical model represented by power-law formalism), we inferred the dynamic network structure which reproduces the actual time-courses within the error allowance of 13.17%. By performing sensitivity analysis, three of the most dominant relations in this network were selected; the control paths from leucine to valine, from methionine to threonine, and from leucine to isoleucine. This result is in good agreement with the biological knowledge regarding branched-chain amino acids, and suggests the biological importance of the effect from methionine to threonine.

Original languageEnglish
Pages (from-to)179-187
Number of pages9
JournalAmino Acids
Volume38
Issue number1
DOIs
Publication statusPublished - Jan 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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