Detoxification system for inorganic arsenic: Transformation of As 2O3 into TMAO by vitamin B12 derivatives and conversion of TMAO into arsenobetaine

Koichiro Nakamura, Yoshio Hisaeda, Ling Pan, Hiroshi Yamauchi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A new two-step synthetic pathway developed for the transformation of arsenic trioxide [iAs(iii); As2O3] into arsenobetaine (AB; Me3As+CH2CO2-) involves treatment of iAs(iii) with native B12 or biomimetic B12 in the presence of glutathione (GSH) to give TMAO with a high selectivity and a high conversion rate; subsequent treatment of TMAO with iodoacetic acid in the presence of GSH gives arsenobetaine.

Original languageEnglish
Pages (from-to)5122-5124
Number of pages3
JournalChemical Communications
Issue number41
DOIs
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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