A new two-step synthetic pathway developed for the transformation of arsenic trioxide [iAs(iii); As2O3] into arsenobetaine (AB; Me3As+CH2CO2-) involves treatment of iAs(iii) with native B12 or biomimetic B12 in the presence of glutathione (GSH) to give TMAO with a high selectivity and a high conversion rate; subsequent treatment of TMAO with iodoacetic acid in the presence of GSH gives arsenobetaine.
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry