Detoxification system for inorganic arsenic

Transformation of As 2O3 into TMAO by vitamin B12 derivatives and conversion of TMAO into arsenobetaine

Koichiro Nakamura, Yoshio Hisaeda, Ling Pan, Hiroshi Yamauchi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A new two-step synthetic pathway developed for the transformation of arsenic trioxide [iAs(iii); As2O3] into arsenobetaine (AB; Me3As+CH2CO2-) involves treatment of iAs(iii) with native B12 or biomimetic B12 in the presence of glutathione (GSH) to give TMAO with a high selectivity and a high conversion rate; subsequent treatment of TMAO with iodoacetic acid in the presence of GSH gives arsenobetaine.

Original languageEnglish
Pages (from-to)5122-5124
Number of pages3
JournalChemical Communications
Issue number41
DOIs
Publication statusPublished - Nov 4 2008

Fingerprint

Detoxification
Vitamins
Biomimetics
Arsenic
Vitamin B 12
Iodoacetic Acid
Derivatives
Acids
Glutathione
arsenobetaine
arsenic trioxide
trimethyloxamine

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Detoxification system for inorganic arsenic : Transformation of As 2O3 into TMAO by vitamin B12 derivatives and conversion of TMAO into arsenobetaine. / Nakamura, Koichiro; Hisaeda, Yoshio; Pan, Ling; Yamauchi, Hiroshi.

In: Chemical Communications, No. 41, 04.11.2008, p. 5122-5124.

Research output: Contribution to journalArticle

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