Detoxification system for inorganic arsenic: Transformation of As 2O3 into TMAO by vitamin B12 derivatives and conversion of TMAO into arsenobetaine

Koichiro Nakamura, Yoshio Hisaeda, Ling Pan, Hiroshi Yamauchi

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    A new two-step synthetic pathway developed for the transformation of arsenic trioxide [iAs(iii); As2O3] into arsenobetaine (AB; Me3As+CH2CO2-) involves treatment of iAs(iii) with native B12 or biomimetic B12 in the presence of glutathione (GSH) to give TMAO with a high selectivity and a high conversion rate; subsequent treatment of TMAO with iodoacetic acid in the presence of GSH gives arsenobetaine.

    Original languageEnglish
    Pages (from-to)5122-5124
    Number of pages3
    JournalChemical Communications
    Issue number41
    DOIs
    Publication statusPublished - 2008

    All Science Journal Classification (ASJC) codes

    • Catalysis
    • Electronic, Optical and Magnetic Materials
    • Ceramics and Composites
    • Chemistry(all)
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

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