Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis

Jiaqi LIU, Chi Tim LEUNG, Luyun LIANG, Yuqin WANG, Jian CHEN, Keng Po LAI, William Ka Fai TSE

Research output: Contribution to journalReview articlepeer-review

Abstract

Deubiquitinases (DUBs) deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate its activity and stability. They are involved in several cellular functions. In addition to the general biological regulation of normal cells, studies have demonstrated their critical roles in various cancers. In this review, we evaluated and grouped the biological roles of DUBs, including proliferation, metastasis, and apoptosis, in the most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung cancers). The current findings in these cancers are summarized, and the relevant mechanisms and relationship between DUBs and cancers are discussed. In addition to highlighting the importance of DUBs in cancer biology, this study also provides updated information on the roles of DUBs in different types of cancers.

Original languageEnglish
Article number3547
JournalCancers
Volume14
Issue number14
DOIs
Publication statusPublished - Jul 2022

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis'. Together they form a unique fingerprint.

Cite this