Deuterium substitution effect on the excited-state dynamics of rhodopsin

T. Kakitani, Ryo Akiyama, Y. Hatano, Y. Imamoto, Y. Shichida, P. Verdegem, J. Lugtenburg

Research output: Contribution to journalArticle

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Abstract

We investigated the excited-state dynamics of the cis-trans photoisomerization of rhodopsin by analyzing deuterium substitution effects for hydrogen atoms bonded to C11 and C12 of the retinal chromophore by the method of Fourier transform of optical absorption spectra (FTOA). Plotting the absolute value of the time correlation function of modified vibrational wave packet, we found that the deuterium substitution effects do not appear in the excited-state dynamics until about 20 fs after photon absorption, weakly appear in the time range 20-60 fs, significantly appear in the time range 70-110 fs, and complicatedly appear in the time range 110-170 fs. By analyzing those deuterium substitution effects, we obtained a result that the concerted motions of hydrogen out-of-plane (HOOP) waggings at C11 and C12, which are found to exist in native rhodopsin in the time range 20-60 fs, do not contribute to the excited-state dynamics in its time range appreciably and that the coupled motions of hydrogen atoms at C11 and C12, which are significantly coupled with the skeletal twisting motion of the chromophore in the time range 70-110 fs, contribute to the excited dynamics in its time range substantially. The hydrogen motions after 110 fs contribute to the excited-state dynamics in a complicate way. This cis-trans photoisomerization process of rhodopsin is basically similar to that of bacteriorhodopsin, which was obtained by the comparative analysis of the FTOA of 13-trans-locked-bacteriorhodopsin with native bacteriorhodopsin.

Original languageEnglish
Pages (from-to)1334-1339
Number of pages6
JournalJournal of Physical Chemistry B
Volume102
Issue number7
Publication statusPublished - Feb 12 1998
Externally publishedYes

Fingerprint

Rhodopsin
Deuterium
Excited states
deuterium
Substitution reactions
Bacteriorhodopsins
substitutes
Hydrogen
Photoisomerization
excitation
Chromophores
Light absorption
Absorption spectra
Fourier transforms
Wave packets
Atoms
chromophores
optical spectrum
hydrogen atoms
optical absorption

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this

Kakitani, T., Akiyama, R., Hatano, Y., Imamoto, Y., Shichida, Y., Verdegem, P., & Lugtenburg, J. (1998). Deuterium substitution effect on the excited-state dynamics of rhodopsin. Journal of Physical Chemistry B, 102(7), 1334-1339.

Deuterium substitution effect on the excited-state dynamics of rhodopsin. / Kakitani, T.; Akiyama, Ryo; Hatano, Y.; Imamoto, Y.; Shichida, Y.; Verdegem, P.; Lugtenburg, J.

In: Journal of Physical Chemistry B, Vol. 102, No. 7, 12.02.1998, p. 1334-1339.

Research output: Contribution to journalArticle

Kakitani, T, Akiyama, R, Hatano, Y, Imamoto, Y, Shichida, Y, Verdegem, P & Lugtenburg, J 1998, 'Deuterium substitution effect on the excited-state dynamics of rhodopsin', Journal of Physical Chemistry B, vol. 102, no. 7, pp. 1334-1339.
Kakitani T, Akiyama R, Hatano Y, Imamoto Y, Shichida Y, Verdegem P et al. Deuterium substitution effect on the excited-state dynamics of rhodopsin. Journal of Physical Chemistry B. 1998 Feb 12;102(7):1334-1339.
Kakitani, T. ; Akiyama, Ryo ; Hatano, Y. ; Imamoto, Y. ; Shichida, Y. ; Verdegem, P. ; Lugtenburg, J. / Deuterium substitution effect on the excited-state dynamics of rhodopsin. In: Journal of Physical Chemistry B. 1998 ; Vol. 102, No. 7. pp. 1334-1339.
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