Development and characterization of porous calcium phosphate cement using α-tricalcium phosphate bead

Pham Trung Kien, Tsuru Kanji, Kunio Ishikawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Interconnected set porous-calcium phosphate cement (set porous-CPC), which has fully interconnected pores could be an ideal bone substitute. In this study, set porous- CPC consisting of α-tricalcium phosphate (α-TCP) beads and acidic calcium phosphate solution was developed and its basic setting reaction was studied. When α-TCP beads were exposed to the acidic calcium phosphate solution, brushite (CaHPO4 ·2H2O) was formed on the surface of the α-TCP beads. The formed brushite crystals interlocked with each other, resulting in a setting reaction of α-TCP microspheres within 10 min at 37°C. As a result of this setting reaction, a fullyinterconnected calcium phosphate macroporous structure was obtained. The set porous-CPC were immersed into simulated body fluid (SBF) at 37oC for different immersion time, The result clearly showed that brushite surface layer transformed to apatite layer after 3 days immersion into SBF solution by dissolution-precipitation reaction. Since apatite layer show excellent tissue response, the set porous-CPC would be a promising biomaterial used as artificial bone substitutes, and as the scaffold for tissue engineering.

Original languageEnglish
Title of host publication5th International Conference on Biomedical Engineering in Vietnam
EditorsVo Van Toi, Tran Ha Lien Phuong
PublisherSpringer Verlag
Pages507-510
Number of pages4
ISBN (Electronic)9783319117751
DOIs
Publication statusPublished - Jan 1 2015
Event5th International Conference on the Development of Biomedical Engineering, 2014 - Ho Chi Minh City, Viet Nam
Duration: Jun 16 2014Jun 18 2014

Publication series

NameIFMBE Proceedings
Volume46
ISSN (Print)1680-0737

Other

Other5th International Conference on the Development of Biomedical Engineering, 2014
CountryViet Nam
CityHo Chi Minh City
Period6/16/146/18/14

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

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    Kien, P. T., Kanji, T., & Ishikawa, K. (2015). Development and characterization of porous calcium phosphate cement using α-tricalcium phosphate bead. In V. V. Toi, & T. H. L. Phuong (Eds.), 5th International Conference on Biomedical Engineering in Vietnam (pp. 507-510). (IFMBE Proceedings; Vol. 46). Springer Verlag. https://doi.org/10.1007/978-3-319-11776-8_125