Development of a computer-aided diagnosis system for continuous peritoneal dialysis: An availability of the simultaneous numerical optimization technique for kinetic parameters in the peritoneal dialysis model

Hiroyuki Hamada, Shinji Namoto, Ryo Yamada, Abdullah Al Mamun, Akihiro C. Yamashita, Makoto Ishizaki, Masahiro Okamoto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We developed a novel diagnostic system for continuous peritoneal dialysis, which evaluates the peritoneal permeability and hydraulic conductance (peritoneal function) by applying the kinetic model and a clinical test with minimum nursing time. Kinetic parameters for the peritoneal function were determined by the simultaneous numerical optimization techniques (SNOT). Furthermore dialysis outcome and ultrafiltration volume were estimated and predicted by using the kinetic model with a set of optimal kinetic parameters, which were in agreement with measured data (r2 > 0.82). The clinical implementation of the SNOT is very useful to explore the better prescriptions for each patient's clinical condition.

Original languageEnglish
Pages (from-to)1700-1708
Number of pages9
JournalComputers in Biology and Medicine
Volume37
Issue number12
DOIs
Publication statusPublished - Dec 2007

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Health Informatics

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