Development of a new redox molecular imaging method

Tatsuya Naganuma, Motonao Nakao, Kazuhiro Ichikawa, Hideo Utsumi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

For indirect tissue observation, electron-spin, Overhauser-enhanced, dynamic nuclear polarization magnetic resonance imaging (DNP-MRI) is a useful technique. However, its sensitivity and resolution are low compared with the clinical MRI apparatus. By switching to electron spin resonance (ESR) excitation, the magnetic field of the NMR detec- tion, field cycle technique, which aims to improve resolution, was proposed. However, the eŠect of eddy currents or cur- rent value was altered unsatisfactorily. A team at Kyushu University proposed a new DNP-MRI technique capable of improving NMR detection field by preparing in advance a magnetic field, which was connected by the sample transport system. By developing a mobile MRI method that can be used while moving, and fastening the sample in a disk that rotates at a constant speed, they have developed a circular transport DNP-MRI method that greatly reduces the load on the sample. The circular transport DNP-MRI system comprises a circular sample transport system, detection of an MRI magnetic field of 1.5 T, and ESR excitation magnetic field of 20 mT. The developed DNP-MRI had a clear glass tube phantom and resolution of 0.15 mm, and was successful in imaging multiple radical resonant points. It has been com- mercialized by Japan Redox Limited. In the process of equipment commercialization, a new digital spectrometer has been developed, which expanded the MRI apparatus.

Original languageEnglish
Pages (from-to)733-738
Number of pages6
JournalYakugaku Zasshi
Volume135
Issue number5
DOIs
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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    Naganuma, T., Nakao, M., Ichikawa, K., & Utsumi, H. (2015). Development of a new redox molecular imaging method. Yakugaku Zasshi, 135(5), 733-738. https://doi.org/10.1248/yakushi.14-00235-3