Development of a novel ionic liquid-curcumin complex to enhance its solubility, stability, and activity

Md Raihan Chowdhury, Rahman Md Moshikur, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto

Research output: Contribution to journalArticle

Abstract

We report a one-step emulsification and rapid freeze-drying process to develop a curcumin-ionic liquid (CCM-IL) complex that could be readily dispersed in water with a significantly enhanced solubility of ∼8 mg mL-1 and half-life (t1/2) of ∼260 min compared with free CCM (solubility ∼30 nM and t1/2 ∼ 20 min). This process using an IL consisting of a long chain carbon backbone as a surfactant, may provide an alternative way of enhancing the solubility of poorly water-soluble drugs.

Original languageEnglish
Pages (from-to)7737-7740
Number of pages4
JournalChemical Communications
Volume55
Issue number54
DOIs
Publication statusPublished - Jan 1 2019

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Ionic Liquids
Curcumin
Ionic liquids
Solubility
Emulsification
Water
Surface-Active Agents
Drying
Surface active agents
Carbon
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Development of a novel ionic liquid-curcumin complex to enhance its solubility, stability, and activity. / Chowdhury, Md Raihan; Moshikur, Rahman Md; Wakabayashi, Rie; Tahara, Yoshiro; Kamiya, Noriho; Moniruzzaman, Muhammad; Goto, Masahiro.

In: Chemical Communications, Vol. 55, No. 54, 01.01.2019, p. 7737-7740.

Research output: Contribution to journalArticle

Chowdhury, Md Raihan ; Moshikur, Rahman Md ; Wakabayashi, Rie ; Tahara, Yoshiro ; Kamiya, Noriho ; Moniruzzaman, Muhammad ; Goto, Masahiro. / Development of a novel ionic liquid-curcumin complex to enhance its solubility, stability, and activity. In: Chemical Communications. 2019 ; Vol. 55, No. 54. pp. 7737-7740.
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