TY - JOUR
T1 - Development of a patient-oriented disease specific outcome measure of health-related quality of life (HRQOL) for musculoskeletal oncology patients
AU - Ogura, Koichi
AU - Uehara, Kosuke
AU - Akiyama, Toru
AU - Shinoda, Yusuke
AU - Iwata, Shintaro
AU - Tsukushi, Satoshi
AU - Kobayashi, Eisuke
AU - Hirose, Takeshi
AU - Yonemoto, Tsukasa
AU - Endo, Makoto
AU - Tanzawa, Yoshikazu
AU - Nakatani, Fumihiko
AU - Kawano, Hirotaka
AU - Tanaka, Sakae
AU - Kawai, Akira
N1 - Funding Information:
This study was funded by a Grant-in-Aid for Scientific Research from the Ministry of Education and Science (B, No. 22390296 ), and by the National Cancer Center Research and Development Fund ( 23-A-10 and 28-A-16 ).
Funding Information:
This study was funded by a Grant-in-Aid for Scientific Research from the Ministry of Education and Science (B, No. 22390296), and by the National Cancer Center Research and Development Fund (23-A-10 and 28-A-16).
Publisher Copyright:
© 2018 The Japanese Orthopaedic Association
PY - 2019/5
Y1 - 2019/5
N2 - Background: According to improved functional outcome and life expectancy in orthopaedic oncology patients, there has been a growing interest in not only oncologic and functional outcomes but also health-related quality of life (HRQOL), including body image, mental status, or social activities, after surgery. However, there has been a lack of disease-specific measures focusing on the ability of orthopaedic oncology patients to evaluate their HRQOL comprehensively. Therefore, our aims in the present study were 1) to develop a patient-oriented disease-specific outcome measure of HRQOL for musculoskeletal oncology patients (COMMON-LE), and 2) to examine the practical applicability, reliability and validity of the COMMON-LE for patients with musculoskeletal tumors in the lower extremity. Methods: The COMMON-LE was developed by expert committee of orthopaedic oncology and rehabilitation. A total of 101 patients were surveyed using the COMMON-LE, as well as the TESS, the MSTS score, and the SF-36, to assess their psychometric characteristics, including reliability, validity, and responsiveness. Results: The COMMON-LE showed no marked floor and ceiling effects. Test-retest reliability and internal consistency determined using the intraclass correlation coefficient (0.928) and Cronbach's alpha (0.948–0.968), respectively, were excellent. Each domain of the COMMON-LE (pain, ADL, socioemotional condition and general health) was well correlated with the scores of the standard measures (SF-36, TESS, MSTS score). Factor analysis and the AIC network showed the questionnaire items of the COMMON-LE were clearly separable into three clusters according to their content, corresponding to each domain of the questionnaire. Conclusions: We have successfully developed and validated a disease-specific measure, the COMMON-LE, to evaluate not only physical function, but also various aspects of HRQOL in patients with musculoskeletal tumors. The COMMON-LE has sufficient reliability and internal consistency, and good validity, and appears to be practically applicable to this group of patients.
AB - Background: According to improved functional outcome and life expectancy in orthopaedic oncology patients, there has been a growing interest in not only oncologic and functional outcomes but also health-related quality of life (HRQOL), including body image, mental status, or social activities, after surgery. However, there has been a lack of disease-specific measures focusing on the ability of orthopaedic oncology patients to evaluate their HRQOL comprehensively. Therefore, our aims in the present study were 1) to develop a patient-oriented disease-specific outcome measure of HRQOL for musculoskeletal oncology patients (COMMON-LE), and 2) to examine the practical applicability, reliability and validity of the COMMON-LE for patients with musculoskeletal tumors in the lower extremity. Methods: The COMMON-LE was developed by expert committee of orthopaedic oncology and rehabilitation. A total of 101 patients were surveyed using the COMMON-LE, as well as the TESS, the MSTS score, and the SF-36, to assess their psychometric characteristics, including reliability, validity, and responsiveness. Results: The COMMON-LE showed no marked floor and ceiling effects. Test-retest reliability and internal consistency determined using the intraclass correlation coefficient (0.928) and Cronbach's alpha (0.948–0.968), respectively, were excellent. Each domain of the COMMON-LE (pain, ADL, socioemotional condition and general health) was well correlated with the scores of the standard measures (SF-36, TESS, MSTS score). Factor analysis and the AIC network showed the questionnaire items of the COMMON-LE were clearly separable into three clusters according to their content, corresponding to each domain of the questionnaire. Conclusions: We have successfully developed and validated a disease-specific measure, the COMMON-LE, to evaluate not only physical function, but also various aspects of HRQOL in patients with musculoskeletal tumors. The COMMON-LE has sufficient reliability and internal consistency, and good validity, and appears to be practically applicable to this group of patients.
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U2 - 10.1016/j.jos.2018.10.020
DO - 10.1016/j.jos.2018.10.020
M3 - Article
C2 - 30446332
AN - SCOPUS:85056376312
SN - 0949-2658
VL - 24
SP - 539
EP - 547
JO - Journal of Orthopaedic Science
JF - Journal of Orthopaedic Science
IS - 3
ER -
