Development of a patient-oriented disease specific outcome measure of health-related quality of life (HRQOL) for musculoskeletal oncology patients

Koichi Ogura, Kosuke Uehara, Toru Akiyama, Yusuke Shinoda, Shintaro Iwata, Satoshi Tsukushi, Eisuke Kobayashi, Takeshi Hirose, Tsukasa Yonemoto, Makoto Endo, Yoshikazu Tanzawa, Fumihiko Nakatani, Hirotaka Kawano, Sakae Tanaka, Akira Kawai

Research output: Contribution to journalArticle

Abstract

Background: According to improved functional outcome and life expectancy in orthopaedic oncology patients, there has been a growing interest in not only oncologic and functional outcomes but also health-related quality of life (HRQOL), including body image, mental status, or social activities, after surgery. However, there has been a lack of disease-specific measures focusing on the ability of orthopaedic oncology patients to evaluate their HRQOL comprehensively. Therefore, our aims in the present study were 1) to develop a patient-oriented disease-specific outcome measure of HRQOL for musculoskeletal oncology patients (COMMON-LE), and 2) to examine the practical applicability, reliability and validity of the COMMON-LE for patients with musculoskeletal tumors in the lower extremity. Methods: The COMMON-LE was developed by expert committee of orthopaedic oncology and rehabilitation. A total of 101 patients were surveyed using the COMMON-LE, as well as the TESS, the MSTS score, and the SF-36, to assess their psychometric characteristics, including reliability, validity, and responsiveness. Results: The COMMON-LE showed no marked floor and ceiling effects. Test-retest reliability and internal consistency determined using the intraclass correlation coefficient (0.928) and Cronbach's alpha (0.948–0.968), respectively, were excellent. Each domain of the COMMON-LE (pain, ADL, socioemotional condition and general health) was well correlated with the scores of the standard measures (SF-36, TESS, MSTS score). Factor analysis and the AIC network showed the questionnaire items of the COMMON-LE were clearly separable into three clusters according to their content, corresponding to each domain of the questionnaire. Conclusions: We have successfully developed and validated a disease-specific measure, the COMMON-LE, to evaluate not only physical function, but also various aspects of HRQOL in patients with musculoskeletal tumors. The COMMON-LE has sufficient reliability and internal consistency, and good validity, and appears to be practically applicable to this group of patients.

Original languageEnglish
Pages (from-to)539-547
Number of pages9
JournalJournal of Orthopaedic Science
Volume24
Issue number3
DOIs
Publication statusPublished - May 2019
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

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