Development of a portable surface plasmon resonance sensor with multi-sensing points based on the linear CCD sensor

Jie Zhan, Koji Furui, Hizuru Nakajima, Noriaki Kaneki, Ryoichi Ishimatsu, Koji Nakano, Toshihiko Imato, Akihide Hemmi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A portable-type surface plasmon resonance (SPR) sensor, composed from a new optical system for multi-sensing, has been developed to apply to environment analysis, clinical diagnosis etc., where many samples are desired to be analyzed at high throughput. The optical system of the sensor consists of a light-emitting diode, a pair of cylindrical lenses, a pair of collimator lenses, a correction lens, a prism, a polarizer and a linear CCD sensor with 2048 pixels. Reflected light from a sensor chip of the width of 6 mm at a certain incident angle was detected by ca. 618 pixels of the linear CCD sensor as an SPR sensor signal. An SPR sensor signal at a specified incident angle is controllable for optimization by adjusting the position of the CCD sensor. A sensor chip having a 30-stripe linear pattern (100 μm width/stripe) was prepared. The spatial resolution as well as the performance of the sensor were evaluated by using sucrose solutions. As a result, the acquisition of SPR sensor signals from 30 sensing points was successfully achieved with a spatial resolution of 100 μm (distance between 2 sensing points). A lower detection limit of ca. 3.2-5.5 × 10-5 RIU with a standard deviation of ±4.5% was obtained by averaging the signals from 6-7 pixels of the CCD sensor per one sensing stripe. 2016.

Original languageEnglish
Pages (from-to)673-679
Number of pages7
Journalanalytical sciences
Volume32
Issue number6
DOIs
Publication statusPublished - Jan 1 2016

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Surface plasmon resonance
Charge coupled devices
Sensors
Lenses
Pixels
Optical systems
Prisms
Light emitting diodes
Sucrose
Throughput

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

Cite this

Development of a portable surface plasmon resonance sensor with multi-sensing points based on the linear CCD sensor. / Zhan, Jie; Furui, Koji; Nakajima, Hizuru; Kaneki, Noriaki; Ishimatsu, Ryoichi; Nakano, Koji; Imato, Toshihiko; Hemmi, Akihide.

In: analytical sciences, Vol. 32, No. 6, 01.01.2016, p. 673-679.

Research output: Contribution to journalArticle

Zhan, Jie ; Furui, Koji ; Nakajima, Hizuru ; Kaneki, Noriaki ; Ishimatsu, Ryoichi ; Nakano, Koji ; Imato, Toshihiko ; Hemmi, Akihide. / Development of a portable surface plasmon resonance sensor with multi-sensing points based on the linear CCD sensor. In: analytical sciences. 2016 ; Vol. 32, No. 6. pp. 673-679.
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