Development of a protease-responsive protein nano capsule for drug carrier

Kentaro Sao; Masaharu Murata; Hiroki Sato; Tatsuhiko Sonoda; Takeshi Mori; Takuro Niidome; Yoshiki Katayama; Makoto Hashizume

Development of a protease-responsive protein nano capsule for drug carrier

Kentaro Sao, Masaharu Murata, Hiroki Sato, Tatsuhiko Sonoda, Takeshi Mori, Takuro Niidome, Yoshiki Katayama, Makoto Hashizume

Research output: Contribution to conference › Paper › peer-review

Abstract

Recently, researches of drug delivery systems (DDS) have been investigated actively. For the accomplishment of DDS, it is important to develop drug carriers. Wile a lot of efforts have been expended, there are no carriers which have enough efficiency. So, we aimed at one protein which is named HSP16.5 for the application to drug carriers. This protein affects nano capsule-like conformation. In many diseases, it is well known that certain proteases have overexpresssed at the lesion regions. We inserted protease recognition amino acid sequences to the HSP16.5. In the presence of target protease, this nano capsule composed of rHSP16.5 could collapse selectively, and it is expected to release the encapsulated drug at pathological areas.

Original language	English
Number of pages	1
Publication status	Published - Oct 19 2006
Event	55th SPSJ Annual Meeting - Nagoya, Japan Duration: May 24 2006 → May 26 2006

Other

Other	55th SPSJ Annual Meeting
Country	Japan
City	Nagoya
Period	5/24/06 → 5/26/06

All Science Journal Classification (ASJC) codes

Engineering(all)

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title = "Development of a protease-responsive protein nano capsule for drug carrier",

abstract = "Recently, researches of drug delivery systems (DDS) have been investigated actively. For the accomplishment of DDS, it is important to develop drug carriers. Wile a lot of efforts have been expended, there are no carriers which have enough efficiency. So, we aimed at one protein which is named HSP16.5 for the application to drug carriers. This protein affects nano capsule-like conformation. In many diseases, it is well known that certain proteases have overexpresssed at the lesion regions. We inserted protease recognition amino acid sequences to the HSP16.5. In the presence of target protease, this nano capsule composed of rHSP16.5 could collapse selectively, and it is expected to release the encapsulated drug at pathological areas.",

author = "Kentaro Sao and Masaharu Murata and Hiroki Sato and Tatsuhiko Sonoda and Takeshi Mori and Takuro Niidome and Yoshiki Katayama and Makoto Hashizume",

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T1 - Development of a protease-responsive protein nano capsule for drug carrier

AU - Sao, Kentaro

AU - Murata, Masaharu

AU - Sato, Hiroki

AU - Sonoda, Tatsuhiko

AU - Mori, Takeshi

AU - Niidome, Takuro

AU - Katayama, Yoshiki

AU - Hashizume, Makoto

PY - 2006/10/19

Y1 - 2006/10/19

N2 - Recently, researches of drug delivery systems (DDS) have been investigated actively. For the accomplishment of DDS, it is important to develop drug carriers. Wile a lot of efforts have been expended, there are no carriers which have enough efficiency. So, we aimed at one protein which is named HSP16.5 for the application to drug carriers. This protein affects nano capsule-like conformation. In many diseases, it is well known that certain proteases have overexpresssed at the lesion regions. We inserted protease recognition amino acid sequences to the HSP16.5. In the presence of target protease, this nano capsule composed of rHSP16.5 could collapse selectively, and it is expected to release the encapsulated drug at pathological areas.

AB - Recently, researches of drug delivery systems (DDS) have been investigated actively. For the accomplishment of DDS, it is important to develop drug carriers. Wile a lot of efforts have been expended, there are no carriers which have enough efficiency. So, we aimed at one protein which is named HSP16.5 for the application to drug carriers. This protein affects nano capsule-like conformation. In many diseases, it is well known that certain proteases have overexpresssed at the lesion regions. We inserted protease recognition amino acid sequences to the HSP16.5. In the presence of target protease, this nano capsule composed of rHSP16.5 could collapse selectively, and it is expected to release the encapsulated drug at pathological areas.

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