Development of a protease-responsive protein nano capsule for drug carrier

Kentaro Sao, Masaharu Murata, Hiroki Sato, Tatsuhiko Sonoda, Takeshi Mori, Takuro Niidome, Yoshiki Katayama, Makoto Hashizume

Research output: Contribution to conferencePaper

Abstract

Recently, researches of drug delivery systems (DDS) have been investigated actively. For the accomplishment of DDS, it is important to develop drug carriers. Wile a lot of efforts have been expended, there are no carriers which have enough efficiency. So, we aimed at one protein which is named HSP16.5 for the application to drug carriers. This protein affects nano capsule-like conformation. In many diseases, it is well known that certain proteases have overexpresssed at the lesion regions. We inserted protease recognition amino acid sequences to the HSP16.5. In the presence of target protease, this nano capsule composed of rHSP16.5 could collapse selectively, and it is expected to release the encapsulated drug at pathological areas.

Original languageEnglish
Number of pages1
Publication statusPublished - Oct 19 2006
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: May 24 2006May 26 2006

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period5/24/065/26/06

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Proteins
Conformations
Amino acids
Peptide Hydrolases
Drug Delivery Systems

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Sao, K., Murata, M., Sato, H., Sonoda, T., Mori, T., Niidome, T., ... Hashizume, M. (2006). Development of a protease-responsive protein nano capsule for drug carrier. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.

Development of a protease-responsive protein nano capsule for drug carrier. / Sao, Kentaro; Murata, Masaharu; Sato, Hiroki; Sonoda, Tatsuhiko; Mori, Takeshi; Niidome, Takuro; Katayama, Yoshiki; Hashizume, Makoto.

2006. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.

Research output: Contribution to conferencePaper

Sao, K, Murata, M, Sato, H, Sonoda, T, Mori, T, Niidome, T, Katayama, Y & Hashizume, M 2006, 'Development of a protease-responsive protein nano capsule for drug carrier', Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan, 5/24/06 - 5/26/06.
Sao K, Murata M, Sato H, Sonoda T, Mori T, Niidome T et al. Development of a protease-responsive protein nano capsule for drug carrier. 2006. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.
Sao, Kentaro ; Murata, Masaharu ; Sato, Hiroki ; Sonoda, Tatsuhiko ; Mori, Takeshi ; Niidome, Takuro ; Katayama, Yoshiki ; Hashizume, Makoto. / Development of a protease-responsive protein nano capsule for drug carrier. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.1 p.
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AU - Sato, Hiroki

AU - Sonoda, Tatsuhiko

AU - Mori, Takeshi

AU - Niidome, Takuro

AU - Katayama, Yoshiki

AU - Hashizume, Makoto

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