Development of a specific fluorescent probe for 8-oxoguanosine.

Sayaka Ono, Zhichun Li, Yohei Koga, Akira Tsujimoto, Osamu Nakagawa, Shigeki Sasaki

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Abstract

8-Oxoguanosine (8-oxoG) is derived from the oxidation of guanosine (dG) and is known to induce transversion mutations (G:C to T:A) in DNA. We have already reported the fluorescent probe "8-oxoG-clamp", which shows a selective fluorescence quenching phenomenon toward 8-oxoG. In this study, attachment of an additional fluorophore to 8-oxoG-clamp was investigated as a strategy for the detection of 8-oxoG by a fluorescence color change attributed to the 8-oxoG-clamp.

Original languageEnglish
Pages (from-to)315-316
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number51
Publication statusPublished - 2007

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ono, S., Li, Z., Koga, Y., Tsujimoto, A., Nakagawa, O., & Sasaki, S. (2007). Development of a specific fluorescent probe for 8-oxoguanosine. Nucleic acids symposium series (2004), (51), 315-316.