Development of a uniaxial mechanical loading device to evaluate osteogenic differentiation of stem cells seeded on a scaffold material

Masakazu Yamada; Takahisa Anada; Taisuke Masuda; Teruko Takano-Yamamoto; Osamu Suzuki

doi:10.1109/MHS.2015.7438233

Development of a uniaxial mechanical loading device to evaluate osteogenic differentiation of stem cells seeded on a scaffold material

Masakazu Yamada, Takahisa Anada, Taisuke Masuda, Teruko Takano-Yamamoto, Osamu Suzuki

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The present study was designed to investigate the effect of the uniaxial mechanical strain on the proliferation and differentiation of mouse mesenchymal stem D1 cells seeded into the octacalcium phosphate (OCP)/ Gelatin (Gel) composite in vitro. The mechanical stimulation with a uniaxial loading device was analyzed by finite element analysis in order to elucidate quantitatively the effect of the strain on D1 cells seeded into the OCP/Gel composite. The results suggest that osteoblastic differentiation of D1 cells is suppressed by overloading of the compressive strain, but promoted if suitable mechanical stress is provided.

Original language	English
Title of host publication	2015 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781479966783
DOIs	https://doi.org/10.1109/MHS.2015.7438233
Publication status	Published - Mar 21 2016
Externally published	Yes
Event	International Symposium on Micro-NanoMechatronics and Human Science, MHS 2015 - Nagoya, Japan Duration: Nov 23 2015 → Nov 25 2015

Other

Other	International Symposium on Micro-NanoMechatronics and Human Science, MHS 2015
Country/Territory	Japan
City	Nagoya
Period	11/23/15 → 11/25/15

All Science Journal Classification (ASJC) codes

Biomedical Engineering
Electrical and Electronic Engineering
Biotechnology
Education

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10.1109/MHS.2015.7438233

Cite this

Yamada, M., Anada, T., Masuda, T., Takano-Yamamoto, T., & Suzuki, O. (2016). Development of a uniaxial mechanical loading device to evaluate osteogenic differentiation of stem cells seeded on a scaffold material. In 2015 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2015 [7438233] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MHS.2015.7438233

Development of a uniaxial mechanical loading device to evaluate osteogenic differentiation of stem cells seeded on a scaffold material. / Yamada, Masakazu; Anada, Takahisa; Masuda, Taisuke et al.

2015 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2015. Institute of Electrical and Electronics Engineers Inc., 2016. 7438233.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Yamada, M, Anada, T, Masuda, T, Takano-Yamamoto, T & Suzuki, O 2016, Development of a uniaxial mechanical loading device to evaluate osteogenic differentiation of stem cells seeded on a scaffold material. in 2015 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2015., 7438233, Institute of Electrical and Electronics Engineers Inc., International Symposium on Micro-NanoMechatronics and Human Science, MHS 2015, Nagoya, Japan, 11/23/15. https://doi.org/10.1109/MHS.2015.7438233

Yamada M, Anada T, Masuda T, Takano-Yamamoto T, Suzuki O. Development of a uniaxial mechanical loading device to evaluate osteogenic differentiation of stem cells seeded on a scaffold material. In 2015 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2015. Institute of Electrical and Electronics Engineers Inc. 2016. 7438233 doi: 10.1109/MHS.2015.7438233

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AU - Suzuki, Osamu

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AB - The present study was designed to investigate the effect of the uniaxial mechanical strain on the proliferation and differentiation of mouse mesenchymal stem D1 cells seeded into the octacalcium phosphate (OCP)/ Gelatin (Gel) composite in vitro. The mechanical stimulation with a uniaxial loading device was analyzed by finite element analysis in order to elucidate quantitatively the effect of the strain on D1 cells seeded into the OCP/Gel composite. The results suggest that osteoblastic differentiation of D1 cells is suppressed by overloading of the compressive strain, but promoted if suitable mechanical stress is provided.

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Development of a uniaxial mechanical loading device to evaluate osteogenic differentiation of stem cells seeded on a scaffold material

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