Development of a uniaxial mechanical loading device to evaluate osteogenic differentiation of stem cells seeded on a scaffold material

Masakazu Yamada, Takahisa Anada, Taisuke Masuda, Teruko Takano-Yamamoto, Osamu Suzuki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The present study was designed to investigate the effect of the uniaxial mechanical strain on the proliferation and differentiation of mouse mesenchymal stem D1 cells seeded into the octacalcium phosphate (OCP)/ Gelatin (Gel) composite in vitro. The mechanical stimulation with a uniaxial loading device was analyzed by finite element analysis in order to elucidate quantitatively the effect of the strain on D1 cells seeded into the OCP/Gel composite. The results suggest that osteoblastic differentiation of D1 cells is suppressed by overloading of the compressive strain, but promoted if suitable mechanical stress is provided.

Original languageEnglish
Title of host publication2015 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479966783
DOIs
Publication statusPublished - Mar 21 2016
Externally publishedYes
EventInternational Symposium on Micro-NanoMechatronics and Human Science, MHS 2015 - Nagoya, Japan
Duration: Nov 23 2015Nov 25 2015

Other

OtherInternational Symposium on Micro-NanoMechatronics and Human Science, MHS 2015
CountryJapan
CityNagoya
Period11/23/1511/25/15

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All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Electrical and Electronic Engineering
  • Biotechnology
  • Education

Cite this

Yamada, M., Anada, T., Masuda, T., Takano-Yamamoto, T., & Suzuki, O. (2016). Development of a uniaxial mechanical loading device to evaluate osteogenic differentiation of stem cells seeded on a scaffold material. In 2015 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2015 [7438233] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MHS.2015.7438233